Abstract: The Ms 80 standard calvet microcalorimeter was used for measuring the thermo-grams of Hela, human breast carcinoma(Bcap-37) and diploid fibroblasts from human fetal lung (2BS) at 37 ℃ under the conditions of normal cell culture and culture in the presence of bioactive materials in Spirulina. There is a difference in the shapes of thermograms beteween tumor cells (Hela, Bcap-37) and normal coll (2BS) under the same condition. The former tended to ascent and the latter was almost parallel to abscissa during the measurements. The cell number was counted and the inhibit rate of growth and the death rate were obtained. The Sp. P was growth inhibitor and lethal to tumo cells, but had no influence on the growth of 2BS at the concentration of 100 μg·ml~(-1).