物理化学学报 >> 1995, Vol. 11 >> Issue (02): 101-106.doi: 10.3866/PKU.WHXB19950202

研究论文 上一篇    下一篇

担载金属卟啉模拟细胞色素P-450的催化丙烯环氧化

索继栓, 李树本, 王弘立   

  1. 中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室|兰州 730000
  • 收稿日期:1993-12-20 修回日期:1994-06-04 发布日期:1995-02-15
  • 通讯作者: 索继栓

Propylene Epoxidation Catalyzed by a Biomimetic System of Cytochrome P450 Supported Metalloporphyrin on SiO2

Suo Ji-Shuang, Li Shu-Ben, Wang Hong-Li   

  1. State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000
  • Received:1993-12-20 Revised:1994-06-04 Published:1995-02-15
  • Contact: Suo Ji-Shuan

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摘要：

制备了SiO2化学键合金属卟啉Mn（TPP）Cl，Mn（TDCPP）Cl的担载配合物催化剂，并与单氧给体次氯酸钠（NaClO）构造了细胞色素P－450单加氧酶模拟体系，并考察了该体系的反应性能及其影响因素．金属卟啉经化学修饰的SiO2担载之后，由于表面官能团与金属中心的轴向配位及刚性载体SiO2对金属卟啉在载体表面很好的位置分离作用，使得金属卟啉的抗氧化性及稳定性显著增加，表现出优良的催化丙烯环氧化反应性能．

关键词: 金属卟啉, 细胞色素P-450, 催化环氧化

Abstract:

SiO2 supports chemically modified by amine, imidazole were prepared and used to support Mn(TPP)Cl, Mn(TDCPP)Cl for constructing the biomimetic systems of cytochrome P-450 with the single oxygen donor (NaClO) as the terminal oxidant. With such catalytic systems, the propylene could be epoxidized under mild conditions in the aqueous solution of sodium hypochlorite. This fair catalytic behavior compared with that of the unsupported Mn(TPP)Cl was ascribed to the axial ligation of organofunctional group on the SiO2 surface to the central metal of the metalloporphyrins, and the site isolation of active centers which would prevent the formation of μ-oxo-dimers.

Key words: Epoxidation, Cytochrome P-450, Metalloporphyrin