物理化学学报 >> 1996, Vol. 12 >> Issue (09): 849-851.doi: 10.3866/PKU.WHXB19960915

研究简报 上一篇    下一篇

微量热法研究药物对肿瘤细胞的诱导分化作用

谭安民,徐波,屈松生   

  1. 武汉大学化学系,武汉 430072|天然药物及仿生药物国家重点实验室,北京 100083
  • 收稿日期:1996-01-29 修回日期:1996-04-25 发布日期:1996-09-15
  • 通讯作者: 屈松生

Microcalorimetric Study on Induced Differentiation of Tumour Cells by Drug

Tan An-Min,Xu Bo,Qu Song-Sheng   

  1. Department of Chemsitry,Wuhan University,Wuhan 430072|National Key Laboratory of Natural and Biomimetric Drugs,Beijing 100083
  • Received:1996-01-29 Revised:1996-04-25 Published:1996-09-15
  • Contact: Qu Song-Sheng

关键词: 微量热法, HL-60细胞, 诱导分化

Abstract:

Sp-Octyl-(8-Chloroadenosine)-3',5'-Cyclophosphate (OCC), a newlysynthesized cAMP analog, strongly induces growth inhibition and differentiation in human promyelocytic leukemia HL-60 cells. The effect of OCC is dose-time dependent. By using the LKB2277 Bioactivity Monitor, we determined the heat production rate of HL-60 cells treated by OCC at different concentrations. It was found that the heat production rate of HL-60 cell treated by OCC gradually decreased to that of normal human neutrophiles.

Key words: Microcalorimetry, OCC;HL-60 cells, Induced differentiation