物理化学学报 >> 1997, Vol. 13 >> Issue (03): 247-251.doi: 10.3866/PKU.WHXB19970312

研究论文 上一篇    下一篇

不同激发波长下ZnPcSP的光敏化能力和抗癌活性

黄剑东,刘尔生,杨素苓,欧阳瑞珍,陈耐生,黄金陵,黄自强,孙建成,许建华   

  1. 福州大学化学系,福州大学功能材料研究所,福州 350002|福建医科大学肿瘤药理研究室,福州 350004
  • 收稿日期:1996-05-21 修回日期:1996-12-03 发布日期:1997-03-15
  • 通讯作者: 黄剑东

The Ability of Photosensitization and Anti-cancer of ZnPcSP under Different Exciting Wavelength

Huang Jian-Dong,Liu Er-Sheng,Yang Su-Ling,Ouyang Rui-Zhen,Chen Nai-Sheng,Huang Jin-Ling,Huang Zi-Qiang,Sun Jian-Cheng,Xu Jian-Hua   

  1. Department of Chemistry,Institute of Functional Materials,Fuzhou University,Fuzhou 350002|Cancer Pharmacology Research Section,Fujian Medical University,Fuzhou 350004
  • Received:1996-05-21 Revised:1996-12-03 Published:1997-03-15
  • Contact: Huang Jian-Dong

摘要:

 研究了激发光的波长对金属酞菁配合物ZnPcSP光敏化产生1O2的能力和光动力抗癌作用的影响. 结果表明,激发波长对ZnPcSP配合物光敏化产生1O2的能力和光动力抗癌作用的影响显示了同样的规律性,波长为670nm的光具有较佳的激发效率. 研究结果同时说明ZnPcSP在光动力治癌中的主要光敏反应机制可能是产生1O2的Ⅱ型反应机制.

关键词: 锌酞菁配合物, 光动力治癌, 光敏化反应, 单重态氧

Abstract:

The effect of wavelength of exciting light upon the ability of photogenerating singlet oxygen (1O2) and of killing cancer cells of ZnPcSP were studied. The results show that the effect on the ability of photogenerating 1O2 and the ability of killing cancer cells has the same tendency, i.e., the light of 670nm possesses the best exciting efficency. The result also suggests that type Ⅱreaction of producing 1O2 is probably the main photosensitive type in PDT of ZnPcSP.

Key words: Zinc phthalocyanine, Photodynamic therapy of cancer, Photosensitive reaction, Singlet oxygen