物理化学学报 >> 1998, Vol. 14 >> Issue (11): 1043-1047.doi: 10.3866/PKU.WHXB19981116

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不同电解质溶液对脂质体Zeta电势的影响

童华, 姚松年   

  1. 武汉大学分析测试科学系，武汉 430072
  • 收稿日期:1997-12-03 修回日期:1998-03-19 发布日期:1998-11-15
  • 通讯作者: 姚松年

Effect of Different Types of Electrolyte on Surface Potential of Liposome of PC and PC-Cholesterol

Tong Hua, Yao Song-Nian   

  1. Department of Analysis and Measurement in Wuhan University,Wuhan 430072
  • Received:1997-12-03 Revised:1998-03-19 Published:1998-11-15
  • Contact: Yao Song-Nian

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关键词: 显微电泳, Zeta电势, 卵磷脂, 胆固醇

Abstract:

Zeta potential of PC and PC-Cholesterol liposome was measured by microelectrophoretic mobility in the presence of different types of electrolyte. A combination of Gouy-Chapman-Stern theory and Poisson-Boltzmann equation was used to describe the regularity of the dependence of Zeta potential on several cations and anions with different valencies. Interaction mechanism of cation, anion and cholesterol with PC polar head group was discussed. The electrostatic force is dominated in influencing the surface potential of liposome.

Key words: Microelectrophoretic, Zeta potential, Phosphatidyl choline(PC), Cholesterol