物理化学学报 >> 1998, Vol. 14 >> Issue (11): 1048-1052.doi: 10.3866/PKU.WHXB19981117

研究简报 上一篇    下一篇

邻氨基苯硫基-1-丙酮缩合反应动力学及机理

李媛, 黄保华, 吕迎潮, 金声, 邢其毅   

  1. 河北师范大学化学系，石家庄 050016|北京大学化学与分子工程学院，北京 100871
  • 收稿日期:1997-12-01 修回日期:1998-04-01 发布日期:1998-11-15
  • 通讯作者: 李媛

The Mechanism and Kinetics of Intramolecular Condensation Reaction of 1,3-Diaryl-3-(2-amino-phenylsulfenyl)-propan-1-one

Li Yuan, Huang Bao-Hua, Lv Ying-Chao, Jin Sheng, Xing Qi-Yi   

  1. Chemistry Department,Hebei Normal University,Shijiazhuang 050016|Institute of Chemistry and Molecular Engineering,Peking University,Beijing 100871
  • Received:1997-12-01 Revised:1998-04-01 Published:1998-11-15
  • Contact: Li Yuan

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关键词: 1, 5-苯并硫氮杂, 缩合反应, 动力学, 机理

Abstract:

The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by six acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.
The results indicate that the reaction proceeds with a general acid catalytic mechanism in the presence of acetic arid, and in lactic arid, in other stronger acids-methanol solution, the mechanism is of a special arid catalytic one. The result also shows that R2 has an effect on the reaction rate.

Key words: 1,5-benzothiazepine, Condensation reaction, Kinetics, Mechanism