物理化学学报 >> 1999, Vol. 15 >> Issue (11): 1005-1010.doi: 10.3866/PKU.WHXB19991110

研究论文 上一篇    下一篇

苯肼-α-环糊精包合物吸附行为的光谱与电化学研究

高作宁, 力虎林   

  1. 兰州大学化学化工学院,兰州 730000
  • 收稿日期:1999-01-22 修回日期:1999-04-12 发布日期:1999-11-15
  • 通讯作者: 力虎林

Spectroscopic and Electrochemical Studies of Phenylhydrazine-α-cyclodextrin lnclusion Complex and Its Adsorption Behaviors

Gao Zuo-Ning, Li Hu-Lin   

  1. College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000
  • Received:1999-01-22 Revised:1999-04-12 Published:1999-11-15
  • Contact: Li Hu-Lin

摘要:

 研究了水溶液体系中α环糊精(α-CD)存在时盐酸苯肼(PH)的光吸收行为及电化学行为.紫外-可见光谱结果表明, 水溶液体系中盐酸苯肼(PH)与α-环糊精(α-CD)可生成1∶1包合物, 经测定该包合物的包合常数(Kf)为178mol-1•dm3; 与未被包合的PH相比较, PH与α-环糊精生成的包合物对光及氧的敏感性质大大降低. 该性质可用于改进盐酸苯肼的保存方法, 并拓宽了其在医药工业中的应用范围.实验还发现水溶液体系中α-环糊精存在时盐酸苯肼的电化学氧化行为得到极大的抑制.

关键词: 苯肼, 包合物, α-环糊精(α-CD), 吸附

Abstract:

Electrochemical and spectral properties of phenylhydrazine hydrochloride (PH) in aqueous solutions in the presence of α-cyclodextrin (α-CD) were investigated. Spectral results indicate that phenylhydrazine hydrochloride can form 1∶1 inclusion complex with α CD in aqueous solutions. The formation constant of the complex, Kf=178 mol-1•dm3,was evaluated by UV spectrometry. It was observed that the light and oxygen sensitivity of the inclusion complex is much lower than that of the uncomplexed PH, this can be used to improve its storage and handling, and also widen its applications in pharmaceutical industry .Furthermore, it was found that its electrochemical oxidability in aqueous solutions can be greatly suppressed in the presence of α-CD.

Key words: Phenylhydrazine, Inclusion complex, α-cyclodextrin, Adsorption