物理化学学报 >> 2001, Vol. 17 >> Issue (05): 389-392.doi: 10.3866/PKU.WHXB20010502

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低同源性蛋白质结构预测

倪立生;毛凤楼;韩玉真;来鲁华   

  1. 北京大学化学与分子工程学院,物理化学研究所 北京分子动态与稳态结构国家重点实验室,北京 100871
  • 收稿日期:2001-01-12 修回日期:2001-03-07 发布日期:2001-05-15
  • 通讯作者: 来鲁华 E-mail:lai@ipc.pku.edu.cn

Low Homologous Protein Structure Prediction

Ni Li-Sheng;Mao Feng-Lou;Han Yu-Zhen;Lai Lu-Hua   

  1. College of Chemistry of Molecular Engineering,Institute of Physical Chemistry,Peking University,State Key Laboratory of Structural Studies for Stable and Unstable Species,Beijing 100871
  • Received:2001-01-12 Revised:2001-03-07 Published:2001-05-15
  • Contact: Lai Lu-Hua E-mail:lai@ipc.pku.edu.cn

关键词: 蛋白质结构预测, 折叠模式识别, 低同源性, 收敛进化, 基因组

Abstract: The development of human genome project calls for more rapid and accurate protein structure prediction method to assign the structure and function of gene products. Threading has been proved to be successful in protein fold assignment,although difficulties remain for low homologous sequences. We have developed a method for solving the sequence rearrangement problem in threading. By reshuffling secondary elements,protein structures with the same spatial arrangement of secondary structures but different connections can be predicted. This method has been proved to be useful in fold recognition for proteins of different evolutionary origin and converge to the same fold.

Key words: Protein structure prediction, Fold recognition, Low homology,  Convergent evolution, Genome