物理化学学报 >> 2001, Vol. 17 >> Issue (07): 662-671.doi: 10.3866/PKU.WHXB20010719

综述 上一篇    

酞菁配合物的结构与其光动力抗癌活性

黄金陵;黄剑东;刘尔生;陈耐生   

  1. 福州大学化学系 福州大学功能材料研究所,福州 350002
  • 收稿日期:2000-12-06 修回日期:2001-03-30 发布日期:2001-07-15
  • 通讯作者: 黄金陵 E-mail:jdhuang@fzu.edu.cn

Some Relationships between Structures and Photodynamic Anti-cancer Activities of Phthalocyanines

Huang Jin-Ling;Huang Jian-Dong;Liu Er-Sheng;Chen Nai-Sheng   

  1. Institute of Research on Functional Materials, Department of Chemistry,Fuzhou U niversity, Fuzhou 350002
  • Received:2000-12-06 Revised:2001-03-30 Published:2001-07-15
  • Contact: Huang Jin-Ling E-mail:jdhuang@fzu.edu.cn

摘要: 光动力治疗是一种正在发展中的治疗癌症的新方法.主要是利用抗癌光敏剂可优先在 肿瘤组织中富集的特性和随后在适当波长的光照下所引发的光敏化反应来杀死癌肿瘤.自198 5年以来,酞菁配合物作为抗癌光敏剂的研究越来越引人注目. 此文在总结51篇参考文献的 基础上,提出了酞菁配合物的结构与其光动力抗癌活性的某些相关性,着重讨论了中心离子 、环取代基、轴向配体对光动力活性和相关物化性质的影响.得出的一个主要的结论是两亲 性酞菁是极具潜力的光敏剂.

关键词: 酞菁配合物, 抗癌光敏剂, 光动力治疗, 构效关系

Abstract: Photodynamic therapy (PDT) is a new and developing method for cancer t reatment involving the preferential uptake of a photosensitizer by tumor and its subsequent activation by light with appropriate wavelength. Phthalocyanines hav e received increasing attention as photosensitizers for PDT since 1985, so that several works have been focused on this area. This paper gives some relationship s between structures and photodynamic anti-cancer activities of phthalocyanines based on 51 related references. The emphasis is directed to the effects of cent ral ions and ring substitutents and axial ligands on the PDT activities and rela tive physical and chemical properties. The main conclusion is that the amphiphil ic character is the promising factor of phthalocyanines for PDT.

Key words: Phthalocyanine, Photosensitizer for therapy of cancer, Photodynamic therapy, Structure-activity relationship