物理化学学报 >> 2004, Vol. 20 >> Issue (02): 169-172.doi: 10.3866/PKU.WHXB20040212

研究论文 上一篇    下一篇

不同介质凝胶体系中草酸钙结晶的研究

欧阳健明;李祥平   

  1. 暨南大学生物矿化与结石病防治研究所,广州 510632
  • 收稿日期:2003-06-17 修回日期:2003-10-20 发布日期:2004-02-15
  • 通讯作者: 欧阳健明 E-mail:toyjm@jnu.edu.cn

Comparative Investigation of Crystallization of Calcium Oxalate in Different Gel Systems

Ouyang Jian-Ming;Li Xiang-Ping   

  1. Institute of Biomineralization and Lithiasis Research, Jinan University ,Guangzhou 510632
  • Received:2003-06-17 Revised:2003-10-20 Published:2004-02-15
  • Contact: Ouyang Jian-Ming E-mail:toyjm@jnu.edu.cn

摘要: 研究了五种不同介质(水、氯化钠、合成尿、正常人尿液和尿石患者尿液)的凝胶体系中草酸钙(CaC2O4)晶体的生长,及各种体系中防石药物柠檬酸钾(K3cit)对CaC2O4生长的影响.没有加K3cit时,CaC2O4晶体以一水草酸钙(calcium oxalate monohydrate, COM)为主要物相,但在氯化钠和合成尿的凝胶体系中同时出现了二水草酸钙(calcium oxalate dihydrate, COD)和三水草酸钙(calcium oxalate trihydrate, COT),肾结石患者尿液中出现COD,而正常人尿液中没有COD和COT生成.加入K3cit后,水、氯化钠和合成尿介质的凝胶体系中,COT的含量显著增加,患者尿液中产生大量COD,而正常人尿液中出现了少量的COD和极个别的COT.COT的增加与低温、体系中高的离子强度及金属离子等因素有关.K3cit具有诱导COD和COT的生成、减小COM晶体比表面积的作用,从而有利于防治草酸钙结石的形成.

关键词: 草酸钙, 凝胶, 柠檬酸钾, 尿结石

Abstract: Crystallization of calcium oxalate (CaC2O4) was comparatively investigated in five gel systems in the absence and presence of potassium citrate (K3cit).The five gelatinous systems include water, sodium chloride, synthesized urine, diluted healthy urine and diluted pathological urine, respectively. In the absence of K3cit, calcium oxalate monohydrate (COM) is the dominant phase. However, calcium oxalate dihydrate (COD) and trihydrate (COT) crystals appeared simultaneously in the gel systems containing sodium chloride or synthesized urine. COD appeared also in the diluted pathological urine, whereas there was not any COD or COT crystals in the diluted healthy urine system. In the presence of K3cit, the percentage of COT increased markedly in the gel systems containing either water, sodium chloride or synthesized urine. A great deal of COD appeared in the diluted pathological urine system, and a few COD and COT appeared in the diluted healthy urine system. The lower temperature, higher ionic strength and the presence of metal ions in the gel systems lead to increase of the percentage of COT crystals. K3cit has the ability to induce the formation of COD and COT, as well as to diminish the sectional area of COM crystals, thus K3cit can prevent and cure calcium oxalate calculi.

Key words: Calcium oxalate, Gel, Potassium citrate, Urinary stone