物理化学学报 >> 2004, Vol. 20 >> Issue (02): 178-181.doi: 10.3866/PKU.WHXB20040214

研究论文 上一篇    下一篇

含VE微胶囊的制备及其控制释放性能研究

包德才;张琼钢;刘袖洞;马小军;袁权   

  1. 中国科学院大连化学物理研究所,大连 116023;渤海大学化学与食品科学学院,锦州 121000
  • 收稿日期:2003-08-04 修回日期:2003-10-27 发布日期:2004-02-15
  • 通讯作者: 马小军 E-mail:maxj@dicp.ac.cn

Preparation of VE Microcapsules and Its Controlled Release Characteristics

Bao De-Cai;Zhang Qiong-Gang;Liu Xiu-Dong;Ma Xiao-Jun;Yuan Quan   

  1. Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023; School of Science of Chemistry and Food, Bohai University, Jinzhou 121000
  • Received:2003-08-04 Revised:2003-10-27 Published:2004-02-15
  • Contact: Ma Xiao-Jun E-mail:maxj@dicp.ac.cn

摘要: 以天然维生素E(VE)为芯材,利用Shirasu porous glass (SPG) 膜乳化结合液中干燥法,制备了粒径单分散的聚苯乙烯(PS)微胶囊.微胶囊的粒径为膜孔径的4倍,粒径单分散系数CV小于0.2.考察了改变PS和VE的比例及微胶囊的粒径对控制释放性能的影响.

关键词: 膜乳化, 液中干燥法, 维生素E, 微胶囊, 控制释放

Abstract: Monodisperse polystyrene(PS) microcapsules containing vitamin E(VE)were prepared by membrane emulsification-dying in liquid technique. The diameter of microcapsules was about 4 times the size of the pore diameter of Shirasu porous glass (SPG) membrane, and the coefficient of variation (CV) of the microcapsule size was less than 0.2, showing a good monodispersity. Furthermore, the effects of the ratio of PS to VE (m/m) and the diameter of microcapsules on the release characteristics were investigated. When the ratio of PS to VE (m/m) is 40/1, the permeability coefficients were 0.71×10-9 and 0.74×10-9 m•s-1 corresponding to the microcapsule diameters of 21.32 and 11.45 μm, and the concentrations of VE released were 8 and 12 mg•L-1 respectively, which conform to the optimal concentration in applications.

Key words: Membrane emulsification, Drying in liquid, Vitamin E, Microcapsule,  Controlled release