物理化学学报 >> 2005, Vol. 21 >> Issue (01): 98-101.doi: 10.3866/PKU.WHXB20050120

研究简报 上一篇    下一篇

载药微乳液相行为的研究

陆杨燕;夏强;夏勇;马全红;顾宁   

  1. 东南大学分子与生物分子电子学教育部重点实验室,纳米科学与技术研究中心; 东南大学化学化工系,南京 210096
  • 收稿日期:2004-06-24 修回日期:2004-09-07 发布日期:2005-01-15
  • 通讯作者: 夏强 E-mail:xiaq@seu.edu.cn

Studies on the Phase Behaviors of Drug-loading Microemulsions

LU Yang-Yan;XIA Qiang;XIA Yong;MA Quan-Hong;GU Ning   

  1. Research Center for Nano-scale Science and Technology, Key Laboratory of Molecular and Biomolecular Electronics, Ministry of Education, Southeast University; Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096
  • Received:2004-06-24 Revised:2004-09-07 Published:2005-01-15
  • Contact: XIA Qiang E-mail:xiaq@seu.edu.cn

摘要: 提出了一种基于相图研究实现纳米药物载体可控制备的方法.采用微乳液控温相图绘制装置绘制了硬脂酸聚烃氧(40)酯(S-40)/聚氧乙烯聚氧丙烯醚嵌段共聚物(F-68)/单硬脂酸甘油酯(GMS)/水体系的拟三元相图,基于电导率测定值确定了微乳液的结构(W/O、双连续相和O/W),该体系同时存在液晶区域.乳化剂S-40/F-68的质量比为7:3.研究了脂溶性药物维甲酸(RA)对微乳液相行为的影响,结果表明RA的加入对微乳液的相行为影响较小.基于相图研究结果制备了维甲酸固体脂质纳米粒(RA-SLN),亚微米粒度分析仪(PCS)测定的平均粒径和透射电镜测试都表明RA-SLN为10 nm左右的球状粒子.

关键词: 微乳液, 相行为, 固体脂质纳米粒, 维甲酸

Abstract: A new method was presented for controllable preparation of nanoscale drug carriers based on the phase behaviors of microemulsions. The pseudoternary phase diagrams for the system polyoxyethylene (40)stearate (S-40)/polyoxyethylene-polyoxypropylene (F-68)/Glycerol monostearate (GMS)/water were obtained at 60 ℃ using home-made apparatus with temperature control.Different structures of microemulsion (W/O,B.C.and O/W) were distinguished by the conductivity measurement, and liquid crystal region was found to be in existence. The mass ratio of S-40 and F-68 was selected to be 7 ∶3. It was concluded that the introduce of retinoic acid (RA) has little influence on the phase behavior of drug-loading microemulsions. Solid lipid nanoparticle (SLN) of retinoic acid was prepared based on the phase behavior results. The mean particle size of RA-SLN determined by PCS is about 10 nm, and TEM images indicate that particles of RA-SLN are spherical with a size about 10 nm. The study on the phase behaviors of drug-loading microemulsions has been proved to be very significative for the controllable preparation of SLN.

Key words: Microemulsions, Phase behavior, Solid lipid nanoparticle, Retinoic acid