物理化学学报 >> 2005, Vol. 21 >> Issue (03): 234-238.doi: 10.3866/PKU.WHXB20050302

研究论文 上一篇    下一篇

头孢唑酮与Triton X-100缔合体系的相互作用

朱君; 钱俊红; 郭荣   

  1. 扬州大学化学化工学院,扬州 225002
  • 收稿日期:2004-07-15 修回日期:2004-09-15 发布日期:2005-03-15
  • 通讯作者: 郭荣 E-mail:guorong@yzu.edu.cn

Interaction of Cephanone with Triton X-100 Aggregates

ZHU Jun; QIAN Jun-Hong; GUO Rong   

  1. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002
  • Received:2004-07-15 Revised:2004-09-15 Published:2005-03-15
  • Contact: GUO Rong E-mail:guorong@yzu.edu.cn

摘要: 抗生素头孢唑酮的加入使得非离子表面活性剂Triton X-100的表面活性降低. 1H-NMR的结果表明,头孢唑酮增溶于胶束极性基团附近.头孢唑酮与Triton X-100胶束的结合常数随Triton X-100含量的增加而下降,但头孢唑酮在Triton X-100胶束相和水连续相之间的分配系数不随Triton X-100含量变化而变化.

关键词: 头孢唑酮, Triton X-100, 表面活性, 聚集数, 结合常数, 分配系数

Abstract: The effects of cephanone on the surface activity and aggregation behavior of Triton X-100 molecule were studied by the methods of surface tension and fluorescence, respectively. The binding constant between cephanone and Triton X-100 micelles was determined by the method of steady state fluorescence. The location of cephanone in Triton X-100 micelles was investigated through nuclear magnetic spectroscopy (NMR). The results showed that the surface activity of Triton X-100 decreased with the increase of cephanone concentration. With the increase of Triton X-100 concentration, the binding constant between cephanone and Triton X-100 micelles decreased, but the distribution coefficient of cephanone between Triton X-100 micelles and water continuous phase kept being invariable. The results of 1H-NMR showed that cephanone was located around the polar group of Triton X-100 micelle.

Key words: Cephanone, Triton X-100, Surface activity, Aggregation number, Binding constant, Distribution coefficient