物理化学学报 >> 2007, Vol. 23 >> Issue (12): 1969 -1973 .doi: 10.3866/PKU.WHXB20071226

研究简报 上一篇    下一篇

磁性微胶囊的制备及其药物缓控释性能

李琳琳; 陈东; 丁明慧; 唐芳琼; 孟宪伟; 任俊; 张琳   

  1. 中国科学院理化技术研究所, 北京 100080; 中国科学院研究生院, 北京 100049
  • 收稿日期:2007-06-14 修回日期:2007-07-30 发布日期:2007-11-30
  • 通讯作者: 唐芳琼 E-mail:tangfq@mail.ipc.ac.cn

Preparation and Controlled Drug Release Properties of Magnetic Microcapsules

LI Lin-Lin; CHEN Dong; DING Ming-Hui; TANG Fang-Qiong; MENG Xian-Wei; REN Jun; ZHANG Lin   

  1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China; Graduate School of the Chinese Academy of Sciences, Beijing 100049, P. R. China
  • Received:2007-06-14 Revised:2007-07-30 Published:2007-11-30
  • Contact: TANG Fang-Qiong E-mail:tangfq@mail.ipc.ac.cn

摘要: 用乳液-凝胶法制备了磁性壳聚糖/海藻酸钠微胶囊. 在壳聚糖/海藻酸钠微胶囊中掺入Fe3O4磁性中空球, 使微胶囊具有磁靶向性能. 以头孢拉定作为模型药物研究了载药磁性微胶囊的载药量、包封率及药物缓控释性能等. 结果表明, 提高头孢拉定的初始浓度可以提高载药量, 却不利于提高药物的包封率. 所制备的微胶囊在各种缓冲溶液中长时间内具有显著的缓释效果, 并具有pH 刺激响应释放的性能, 即在模拟胃液中的药物释放率大大降低, 而在模拟体液和肠液中的释放时间大大延长, 可达50 h以上. 另外, 在外加磁场作用下, 微胶囊表现出良好的磁定向运动性能, 为磁靶向药物输送提供基础.

关键词: 微胶囊, 磁靶向, 药物缓控释, 磁性中空球, pH 刺激响应, 壳聚糖

Abstract: Magnetic chitosan-alginate microcapsules were prepared via emulsion-gel method. Fe3O4 magnetic hollow spheres were capsulated into the microcapsules, which endowed the microcapsules with magnetic targeting properties. Cefradine was used as model drug to study the properties of the microcapsules including drug content,encapsulation efficiency, and controlled drug release. The results showed that with the increasing of initial drug concentration, the drug content increased, but the encapsulation efficiency decreased. The microcapsules exhibited sustained release of the drug in all media and the release rate could be regulated by the pH value: in simulated gastric fluid, the release rate was greatly decreased, and in simulated body fluid and intestinal fluid, the microcapsules exhibited a constant release in 50 h with different release rates. Under an external magnetic field, the microcapsules showed fine magnetic response properties, which provided possibility for magnetic targeting drug delivery.

Key words: Microcapsule, Magnetic targeting, Controlled drug release, Magnetic hollow spheres, pH-responsive, Chitosan

MSC2000: 

  • O648