物理化学学报 >> 2009, Vol. 25 >> Issue (06): 1059-1064.doi: 10.3866/PKU.WHXB20090529

研究论文 上一篇    下一篇

磁搅拌条件下β-环糊精与亚砷酸钠加合物的形成、谱学特性与热分解行为

党政, 宋乐新, 潘淑臻, 王莽   

  1. 中国科学技术大学化学系, 合肥 230026
  • 收稿日期:2009-01-06 修回日期:2009-02-18 发布日期:2009-06-05
  • 通讯作者: 宋乐新 E-mail:solexin@ustc.edu.cn

Preparation, Spectral Properties and Decomposition Behavior of a Novel β-Cyclodextrin and Sodium Arsenite Adduct Formed by Stirring

DANG Zheng, SONG Le-Xin, PAN Shu-Zhen. WANG Mang   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China
  • Received:2009-01-06 Revised:2009-02-18 Published:2009-06-05
  • Contact: SONG Le-Xin E-mail:solexin@ustc.edu.cn

摘要:

傅里叶变换利用红外光谱、粉末X射线衍射、微分热重分析、气相色谱-飞行时间质谱、紫外光谱、1H核磁滴定以及电喷雾质谱等分析手段对β-环糊精(β-CD)和亚砷酸钠(SA)形成的分子-离子加合物SA-β-CD进行了详细表征. 结果显示, 主-客体之间分子-离子相互作用是导致SA-β-CD的谱学特性(在固态或在溶液中)与热分解行为相异于主、客体自身行为的重要原因. 而在气相色谱-飞行时间质谱条件下发生的氧化还原反应以及在电喷雾质谱条件下出现的Na+-β-CD(摩尔比为1:1)超分子离子复合体进一步揭示了这种分子-离子加合作用的复杂性与独特性.

关键词: β-环糊精, 亚砷酸钠, 加合物, 分子-离子相互作用, 无机药物

Abstract:

We report on the formation of a molecule-ion adduct of β-cyclodextrin (β-CD) with sodium arsenite (SA) both in solid state and in aqueous solution. The adduct was characterized using Fourier transforminfrared spectroscopy, powder X-ray diffraction, differential thermogravimetric analysis, gas chromatography coupled to time-of-flight mass spectrometry, UV-Vis spectroscopy, 1H nuclear magnetic resonance titration and electrospray ionization mass spectroscopy. We found that a weak molecule-ion interaction was responsible for the difference in spectral properties in solid state and in aqueous solution as well as for the difference in thermal decomposition behavior between β-CD, SA and the adduct. The novelty and complexity of this interesting molecule-ion interaction was revealed by a redox reaction based on the data of gas chromatograph coupled to time-of-flight mass spectrometer and by the formation of the 1:1 (molar ratio) supramolecular ion complex, Na+-β-CD, based on its electrospray ionization mass spectrum.

Key words: β-Cyclodextrin, Sodium arsenite, Adduct, Molecule-ion interaction, Inorganic drug

MSC2000: 

  • O643