物理化学学报 >> 2011, Vol. 27 >> Issue (09): 2239-2243.doi: 10.3866/PKU.WHXB20110834

材料物理化学 上一篇    下一篇

双孔道管状有序介孔炭对维生素B12的吸附缓释性能

王小蓉, 郝广平, 陆安慧, 李文翠   

  1. 精细化工国家重点实验室, 大连理工大学化工学院, 辽宁大连 116023
  • 收稿日期:2011-04-18 修回日期:2011-06-14 发布日期:2011-08-26
  • 通讯作者: 李文翠 E-mail:wencuili@dlut.edu.cn
  • 基金资助:

    高等学校博士学科点专项科研基金(20100041110017) 资助项目

Adsorption and Release Behavior of Vitamin B12 in Tubular Structured Ordered Mesoporous Carbon

WANG Xiao-Rong, HAO Guang-Ping, LU An-Hui, LI Wen-Cui   

  1. State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, Liaoning Province, P. R. China
  • Received:2011-04-18 Revised:2011-06-14 Published:2011-08-26
  • Contact: LI Wen-Cui E-mail:wencuili@dlut.edu.cn
  • Supported by:

    The project was supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (20100041110017).

摘要: 通过纳米铸型法, 以硅基介孔分子筛SBA-15 为模板, 糠醇为碳源, 草酸作为聚合催化剂合成了具有双孔道管状有序介孔炭CMK-5. 利用粉末X射线衍射(XRD)、扫描电子显微镜(SEM)和氮气物理吸附法等对其结构进行了表征. 结果表明合成的CMK-5 具有有序结构, 比表面积和孔容积分别高达1856 m2·g-1和2.10 cm3·g-1, 在3.1 和5.5 nm具有集中的双孔分布. 由于独特的双孔道结构特点, CMK-5 在120 min 内快速吸附维生素B12 至平衡, 吸附量高达943 mg·g-1, 远高于商用活性炭. CMK-5 吸附维生素B12 后可以直接用于缓释, 动态缓释浓度维持在~9 mg·L-1, 适用于维生素B12分子在人体内的缓释.

关键词: 有序介孔炭, 双孔道, 维生素B12, 吸附, 药物缓释

Abstract: Ordered mesoporous carbon with hexagonal arrays consisting of tubular-type pores (CMK-5) was synthesized via a nanocasting process by the direct use of SBA-15 as a template, furfuryl alcohol as a carbon source and oxalic acid as the catalyst. The structure of CMK-5 was analyzed by different techniques including scanning electron microscopy, powder X-ray diffraction and N2 adsorption analysis. The specific surface area and pore volume were found to be 1856 m2·g-1 and 2.10 cm3·g-1, respectively, with mesopore sizes concentrated at 3.1 and 5.5 nm. Because of the unique structure the adsorption capacities of CMK-5 towards vitamin B12 was found to be as high as 943 mg·g-1 in a short period of 120 min, which is significantly higher than that of commercial activated carbon. The composites of CMK-5 and vitamin B12 without any treatment gave slow-release performance in a simulated body fluid. The concentration of the release solutions remained 9 mg·L-1 under dynamic conditions. A high loading capacity and slow release rate of vitamin B12 on the CMK-5 support suggested that CMK-5 might have a potential application in drug delivery.

Key words: Ordered mesoporous carbon, Dual-model pore channel, Vitamin B12, Adsorption, Drug release

MSC2000: 

  • O647