物理化学学报 >> 2012, Vol. 28 >> Issue (04): 885-891.doi: 10.3866/PKU.WHXB201202202

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不同浓度和温度时无机盐和尿素对抗抑郁剂药物丙咪嗪盐酸盐的胶束化行为的影响

KABIR-UD-DIN, RUB Malik Abdul, NAQVI Andleeb Z.   

  1. Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
  • 收稿日期:2011-11-30 修回日期:2012-02-01 发布日期:2012-03-21
  • 通讯作者: KABIR-UD-DIN E-mail:kabir7@rediffmail.com
  • 基金资助:

    The project was supported by the Council of Scientific and Industrial Research, New Delhi, India (01 (2208)/08/EMR-II).

Effect of Inorganic Salts and Ureas on the Micellization Behavior of Antidepressant Drug Imipramine Hydrochloride at Various Concentrations and Temperatures

KABIR-UD-DIN, RUB Malik Abdul, NAQVI Andleeb Z.   

  1. Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
  • Received:2011-11-30 Revised:2012-02-01 Published:2012-03-21
  • Contact: KABIR-UD-DIN E-mail:kabir7@rediffmail.com
  • Supported by:

    The project was supported by the Council of Scientific and Industrial Research, New Delhi, India (01 (2208)/08/EMR-II).

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摘要： In the present study we report the micellization behavior of imipramine hydrochloride (IMP) inabsence and presence of different concentrations of inorganic salts (LiCl, NaF, NaCl, NaBr, and KCl) andureas (urea and thiourea) over the temperature range from 288.15 to 303.15 K. The critical micellizationconcentrations (cmc) of drug and drug+additive systems were determined by conductometric technique.With increasing temperature the cmc first increases then decreases. Maximum cmc values were obtainedat 293.15 K with or without additives. In presence of inorganic salts the cmc value decreases which isexplained on the basis of nature and ion size of the added ion. Urea and thiourea also decrease the cmc atlow concentrations (0.2 mmol·L-1 urea and 0.1 mmol·L-1 thiourea), but, at higher concentrations, increasein cmc is observed. The related thermodynamic parameters are also evaluated and discussed.

关键词: Antidepressant drug, Imipramine hydrochloride, Critical micelle concentration, Conductivity, Inorganic salt

Abstract: In the present study we report the micellization behavior of imipramine hydrochloride (IMP) in absence and presence of different concentrations of inorganic salts (LiCl, NaF, NaCl, NaBr, and KCl) and ureas (urea and thiourea) over the temperature range from 288.15 to 303.15 K. The critical micellization concentrations (cmc) of drug and drug+additive systems were determined by conductometric technique. With increasing temperature the cmc first increases then decreases. Maximum cmc values were obtained at 293.15 K with or without additives. In presence of inorganic salts the cmc value decreases which is explained on the basis of nature and ion size of the added ion. Urea and thiourea also decrease the cmc at low concentrations (0.2 mmol·L-1 urea and 0.1 mmol·L-1 thiourea), but, at higher concentrations, increase in cmc is observed. The related thermodynamic parameters are also evaluated and discussed.

Key words: Antidepressant drug, Imipramine hydrochloride, Critical micelle concentration, Conductivity, Inorganic salt