物理化学学报 >> 2012, Vol. 28 >> Issue (06): 1520-1524.doi: 10.3866/PKU.WHXB201203131

材料物理化学 上一篇    下一篇

功能化氧化石墨烯的细胞相容性

张晓1,2, 杨蓉2, 王琛2, 衡成林1   

  1. 1. 北京理工大学物理学院, 教育部簇科学重点实验室, 北京 100081;
    2. 国家纳米科学中心, 中国科学院纳米生物效应与安全性重点实验室, 北京 100190
  • 收稿日期:2011-11-25 修回日期:2012-03-11 发布日期:2012-05-17
  • 通讯作者: 杨蓉, 衡成林 E-mail:yangr@nanoctr.cn; hengcl@bit.edu.cn
  • 基金资助:

    国家自然科学基金(20911130229, 21073047)和中国科学院知识创新工程重要方向项目(KJCX2.YW.M15)资助

Cell Biocompatibility of Functionalized Graphene Oxide

ZHANG Xiao1,2, YANG Rong2, WANG Chen2, HENG Cheng-Lin1   

  1. 1. Key Laboratory of Cluster Science of Ministry of Education, School of Physics, Beijing Institute of Technology, Beijing 100081, P. R. China;
    2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
  • Received:2011-11-25 Revised:2012-03-11 Published:2012-05-17
  • Contact: YANG Rong, HENG Cheng-Lin E-mail:yangr@nanoctr.cn; hengcl@bit.edu.cn
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (20911130229, 21073047) and Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences, China (KJCX2.YW.M15).

摘要: 采用改进的Hummers方法制备了纳米尺度的氧化石墨烯. 对氧化石墨烯的表面进行羧基化, 并连接上聚乙二醇(PEG)使其在细胞培养液中可溶并能稳定保存. 采用透射电镜(TEM)、傅里叶变换红外(FTIR)光谱和zeta 电位测量等对修饰后的氧化石墨烯的结构和功能进行了表征. 体外细胞实验表明PEG修饰的氧化石墨烯在水中具有良好的可溶性, 对A549细胞没有明显的毒性, 在生物医药领域具有潜在的应用价值.

关键词: 氧化石墨烯, 纳米材料, 生物相容性, 表面功能化

Abstract: We report on synthesis of nanoscale graphene oxide (NGO) by modified Hummers’method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.

Key words: Graphene oxide, Nanomaterials, Biocompatibility, Surface functionalization

MSC2000: 

  • O645