物理化学学报 >> 2014, Vol. 30 >> Issue (7): 1363-1369.doi: 10.3866/PKU.WHXB201405063

生物物理化学 上一篇    下一篇

无种子法纳米金棒的制备及其对肿瘤细胞光热治疗效应研究

王新环1,2, 韩秋森2, 李婧影2, 杨蓉2, 刁国旺1, 王琛2   

  1. 1. 扬州大学化学化工学院, 江苏扬州 225002;
    2. 国家纳米科学中心, 纳米生物效应与安全性重点实验室, 北京 100190
  • 收稿日期:2014-03-17 修回日期:2014-05-06 发布日期:2014-06-30
  • 通讯作者: 杨蓉, 刁国旺, 王琛 E-mail:yangr@nanoctr.cn;gwdiao@yzu.edu.cn;wangch@nanoctr.cn
  • 基金资助:

    国家自然科学基金(21261130090,21073047)和中国科学院先导科技专项(XDA09030303)资助项目

Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy

WANG Xin-Huan1,2, HAN Qiu-Sen2, LI Jing-Ying2, YANG Rong2, DIAO Guo-Wang1, WANG Chen2   

  1. 1. College of Chemistry and Chemical Engineering, University of Yangzhou, Yangzhou 225002, Jiangsu Province, P. R. China;
    2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
  • Received:2014-03-17 Revised:2014-05-06 Published:2014-06-30
  • Contact: YANG Rong, DIAO Guo-Wang, WANG Chen E-mail:yangr@nanoctr.cn;gwdiao@yzu.edu.cn;wangch@nanoctr.cn
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (21261130090, 21073047) and Special Fund for Pilot Technology of Chinese Academy of Sciences (XDA09030303).

摘要:

采用简便快捷的无种子法一步完成了纳米金棒的制备. 通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移. 将巯基聚乙二醇(PEG-SH)置换金棒表面的十六烷基三甲基溴化铵(CTAB)分子,大大提高了金棒的生物相容性. 制备的纳米金棒在近红外(NIR)光照射下对肿瘤细胞有很好的杀伤效果.研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础.

关键词: 纳米金棒, 等离子共振吸收, 生物相容性, 表面修饰, 热疗

Abstract:

We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammoniumbromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cell growth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.

Key words: Gold nanorod, Plasmon resonance absorption, Biocompatibility, Surface functionalization, Hyperthermia

MSC2000: 

  • O644