物理化学学报 >> 2015, Vol. 31 >> Issue (7): 1359-1364.doi: 10.3866/PKU.WHXB201504131

软物质 上一篇    下一篇

利用烷基糖苷迁移和扩张共轭亚油酸囊泡pH窗口

马洁, 樊晔, 方云   

  1. 江南大学化学与材料工程学院, 食品胶体与生物技术教育部重点实验室, 江苏无锡214122
  • 收稿日期:2015-02-09 修回日期:2015-04-13 发布日期:2015-07-08
  • 通讯作者: 方云 E-mail:yunfang@126.com
  • 基金资助:

    国家自然科学基金(21276113)资助项目

Influence of Alkyl Polyglucoside on Migration and Extension of pH Window for Forming Fatty Acid Vesicles of Conjugated Linoleic Acid

MA Jie, FAN Ye, FANG Yun   

  1. Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, Jiangsu Province, P. R. China
  • Received:2015-02-09 Revised:2015-04-13 Published:2015-07-08
  • Contact: FANG Yun E-mail:yunfang@126.com
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (21276113).

摘要:

脂肪酸囊泡(FAV)具有与脂质体类似的中空核壳结构, 且原料来源广泛, 绿色安全, 在包埋/缓释方面有重要意义. 但FAV对pH值依赖性强, pH窗口很窄并偏离生命体系适应pH范围, 限制了其作为包埋/缓释体在日用化学品及外用药等中的应用. 本文用绿色安全非离子表面活性剂烷基糖苷(APG)使共轭亚油酸(CLA)形成FAV的pH窗口从原先的8.0-9.0 迁移并扩张至6.0-8.0, 从而与生命体系适应pH值范围相匹配, 并探讨了改善FAV的pH值依赖性和敏感性的原理.

关键词: 脂肪酸囊泡, pH窗口, 共轭亚油酸, 烷基糖苷

Abstract:

Fatty acid vesicles (FAVs) have hollow core-shell structures similar to those of liposomes, and the building block fatty acids are naturally abundant, green, and safe; therefore, FAVs have potential applications in embedding/release systems. However, FAVs are pH sensitive, and the pH window for FAV formation is narrow and biologically unsuitable. These disadvantages prevent FAVs from being used in domestic chemicals and externally applied agents. In this study, a green and safe nonionic surfactant, alkyl polyglucoside (APG), was blended with a model fatty acid conjugated linoleic acid (CLA) to help the latter to form FAVs in a biologically suitable pH window. The experimental results showed that mixing CLA with APG changed the pH window from 8.0-9.0 for CLA to 6.0-8.0 for CLA-APG; this matches the biologically suitable pH range. Methods for improving the pH dependence of FAV formation and the pH-sensitive properties of FAVs were investigated.

Key words: Fatty acid vesicle, pH window, Conjugated linoleic acid, Alkyl polyglucoside

MSC2000: 

  • O648