物理化学学报 >> 2016, Vol. 32 >> Issue (5): 1072-1086.doi: 10.3866/PKU.WHXB201603071

综述 上一篇    下一篇

PEO-PPO嵌段聚醚的聚集行为及其在药物载体领域的应用

刘腾1,*(),汪海洋1,徐桂英2   

  1. 1 山东省医学科学院药物研究所,济南250062
    2 山东大学,胶体与界面化学教育部重点实验室,济南250100
  • 收稿日期:2015-12-23 发布日期:2016-05-07
  • 通讯作者: 刘腾 E-mail:liuteng823@163.com
  • 作者简介:刘腾,1986年生。山东省医学科学院药物研究所,助理研究员。取得山东大学胶体与界面化学博士学位。主讲课程:物理化学,药剂学。研究领域:表面活性剂在药物载体领域的应用|汪海洋,1978生。山东省医学科学院药物研究所,助理研究员。取得山东大学制药工程硕士学位。主讲课程:药事管理学,新药研发与申报。主要从事新药研发工作,获国家新药证书2项|徐桂英,1949年生。山东大学化学与化工学院,教授,博士生导师。主讲课程:表面活性剂物理化学,两亲分子聚集体化学。研究领域:两亲分子物化性能与应用研究,计算机模拟在两亲分子研究中的应用,油田化学
  • 基金资助:
    国家科技重大专项基金(2011ZX05024-004-08);山东省优秀中青年科学家科研奖励基金(BS2014YY005)

Aggregation Behavior of PEO-PPO Block Polyethers and Their Application as a Drug Carrier

Teng LIU1,*(),Hai-Yang WANG1,Gui-Ying XU2   

  1. 1 Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, P. R. China
    2 Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, P. R. China
  • Received:2015-12-23 Published:2016-05-07
  • Contact: Teng LIU E-mail:liuteng823@163.com
  • Supported by:
    the Special Program for Major Research of the Science and Technology, China(2011ZX05024-004-08);Foundation for Outstanding Young Scientist in Shandong Province, China(BS2014YY005)

摘要:

聚氧乙烯-聚氧丙烯(PEO-PPO)嵌段聚醚是一类非离子型高分子表面活性剂,其结构具有很多独特之处:分子结构具有丰富的可设计性,强烈的温度依赖的胶束化行为以及溶剂选择的多样性,这些都极大丰富了其在溶液中自组装形成聚集体的研究内容。本文结合本课题组的工作着重综述了近期国内外有关线型和支状PEO-PPO嵌段聚醚在水溶液中聚集特性的研究进展,以及酸/碱、无机盐、醇类、小分子表面活性剂和聚合物等添加剂对其聚集行为的影响。PEO-PPO嵌段聚醚具有良好的生物相容性,在水溶液中能形成以PPO链段为疏水内核, PEO链段为亲水外壳的胶束结构,该结构非常适于作为疏水药物的载体。因此本文还综述了此类嵌段聚醚作为药物载体方面的研究成果,期望为药物剂型的开发研究提供理论支持。

关键词: Pluronic, Tetronic, 支状嵌段聚醚, 聚集特性, 药物载体

Abstract:

Poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) block polyethers are typical nonionic polymeric surfactants, which allow for wide structural design, exhibit temperature-dependent micellization of the copolymers, and function in a variety of solvent systems. It greatly enriched the investigation of their aggregation behaviors in various solutions. In this paper, an overview based on our research work was provided about the basic properties of linear and branched PEO-PPO block polyethers in aqueous solutions. Furthermore, the effects of additives including acid/base, inorganic salts, alcohols, surfactants and polymers on the aggregation behaviors of PEO-PPO polyethers are examined. PEO-PPO block polyethers have good biocompatibility. They can form micelles in aqueous solutions, with a hydrophobic core and a hydrophilic corona around the micelle interior. This micelle structure provides local hydrophobic microenvironments for hydrophobic drugs. Thus, the application of PEO-PPO polyethers in the field of drug delivery is presented; they can be the theoretical dosage support structure in future drug discovery research.

Key words: Pluronic, Tetronic, Branched block polyether, Aggregation behavior, Drug carrier

MSC2000: 

  • O647