物理化学学报 >> 2017, Vol. 33 >> Issue (1): 63-79.doi: 10.3866/PKU.WHXB201608233

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纳米材料-蛋白质界面相互作用的分子机制

侯静菲,杨延莲*(),王琛*()   

  • 收稿日期:2016-06-01 发布日期:2016-12-29
  • 通讯作者: 杨延莲,王琛 E-mail:yangyl@nanoctr.cn;wangch@nanoctr.cn
  • 作者简介:侯静菲, 1988年生。2011年毕业于北京科技大学, 2011年至今就读于中国科学院国家纳米科学中心物理化学专业。主要研究方向为蛋白质/多肽分子相互作用、组装规律及结构调控|杨延莲,国家纳米科学中心研究员、博士生导师。分别于1996年和1999年获得山东大学学士和硕士学位, 2002年获得北京大学博士学位。研究领域:疾病相关的多肽组装结构及其调控的分子机制;基于扫描探针显微技术的纳米表征方法|王琛,国家纳米科学中心研究员、博士生导师、杰青、中国生物物理学会常务理事、中国真空学会理事等, 1992年获得美国弗吉尼亚大学博士学位。研究领域:扫描探针显微技术及应用;单分子化学和物理性质;分子纳米结构设计、构筑和表征等
  • 基金资助:
    国家自然科学基金(21273051)

Molecular Mechanisms of Interface Interactions between Nanomaterials and Proteins

Jing-Fei HOU,Yan-Lian YANG*(),Chen WANG*()   

  • Received:2016-06-01 Published:2016-12-29
  • Contact: Yan-Lian YANG,Chen WANG E-mail:yangyl@nanoctr.cn;wangch@nanoctr.cn
  • Supported by:
    the National Natural Science Foundation of China(21273051)

摘要:

纳米材料由于其优异的性能在化工、电子、机械、环境、能源、航天等各个领域已经得到了广泛的应用,并且在生物医学方面的应用越来越受到重视。纳米材料-蛋白质界面相互作用是纳米生物医学领域重要的科学问题,对于纳米材料的生物医学应用以及生物安全性评价至关重要。蛋白质分子与纳米材料在界面的相互作用,一方面可以诱导蛋白质的构象、组装结构甚至功能的改变,另一方面可以引起纳米材料的表面亲疏水性、电荷性质等表面物理化学性质的改变。基于蛋白质与纳米材料相互作用检测技术及结果,本文从分子水平阐述了纳米材料与蛋白质分子在界面之间的相互作用机理及相应的结构与性质的变化,从而可以深化对两者之间复杂的相互作用机制的理解,对于推进纳米材料在生物医学的应用及健康、安全、持续发展具有重要意义。

关键词: 纳米材料, 蛋白质, 界面, 相互作用, 生物医学应用, 分子机制

Abstract:

Nanomaterials have excellent properties and have been used widely in chemical engineering, electronics, mechanics, environment, energy, aerospace, and many other fields in recent years. Besides, nanomaterials have attracted increasing attention in the biomedical field. The interactions between nanomaterials and protein molecules are not only significant to the basic science of the biomedical field, but also crucial for the evaluation of biomedical applications and biosafety of nanomaterials. The interfacial interactions between proteins and nanomaterials could induce a series of changes to the structures and functions of proteins, such as the transformation of protein conformations, and the modulation of aggregation states, which would influence the functions of the protein molecules. Interfacial interactions can also influence the physicochemical features of nanomaterials, including morphology, size, hydrophilicity/hydrophobicity, and surface charge density. In this review we explained the molecular level mechanisms for the interactions between nanomaterials and proteins at the interface based on the detection technologies, and discussed the changes in physical and chemical features, structures, and functions. We envision this review could be helpful for the deeper understanding of the complicated interactions between nanomaterials and proteins, and could be beneficial for promoting the healthy, safe, and sustainable development and application of nanomaterials in the biological and medical fields.

Key words: Nanomaterial, Protein, Interface, Interaction, Biological and medical application, Molecular mechanism

MSC2000: 

  • O647