物理化学学报 >> 2017, Vol. 33 >> Issue (7): 1446-1452.doi: 10.3866/PKU.WHXB201704102

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聚丙烯酸功能化高效发光的La1-xEuxF3纳米晶合成及细胞成像

陈凡1,王中跃1,*(),张艳艳1,余柯涵1,翁丽星2,韦玮1,*()   

  1. 1 南京邮电大学光电工程学院,南京210023
    2 南京邮电大学信息材料与纳米研究院,南京210023
  • 收稿日期:2017-01-03 发布日期:2017-05-31
  • 通讯作者: 王中跃,韦玮 E-mail:zywang@njupt.edu.cn;weiwei@njupt.edu.cn
  • 基金资助:
    国家重点基础研究发展计划项目(2012CB933301);国家自然科学基金项目(51502144)

Synthesis of Poly(acrylic acid)-Functionalized La1-xEuxF3 Nanocrystals with High Photoluminescence for Cellular Imaging

Fan CHEN1,Zhong-Yue WANG1,*(),Yan-Yan ZHANG1,Ke-Han YU1,Li-Xing WENG2,Wei WEI1,*()   

  1. 1 School of Optoelectronic Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China
    2 Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China
  • Received:2017-01-03 Published:2017-05-31
  • Contact: Zhong-Yue WANG,Wei WEI E-mail:zywang@njupt.edu.cn;weiwei@njupt.edu.cn
  • Supported by:
    the National Basic Research Program of China(2012CB933301);National Natural Science Foundation of China(51502144)

摘要:

采用水热合成一锅法制备了聚丙烯酸功能化单分散的La1-xEuxF3纳米颗粒(La1-xEuxF3@PAA NPs)。利用透射电子显微镜(TEM)、X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)和光致发光光谱(PL)对样品的形貌、结构、组成和荧光性能进行表征。该纳米颗粒平均粒径为(7±3)nm,具有较好的分散性、稳定性与生物相容性。将纳米颗粒与HeLa癌细胞共同孵育,体外成像结果表明材料对HeLa癌细胞显示出低细胞毒性。用水热法制备的La1-xEuxF3@PAA纳米颗粒可以作为光学荧光探针用于细胞成像,在生物医学领域表现出巨大的潜力。

关键词: 稀土纳米颗粒, 水热法, 水分散液, 高效发光, 生物成像

Abstract:

Monodisperse La1-xEuxF3 nanoparticles (NPs) were functionalized by poly(acrylic acid) (PAA) via a one-pot modified hydrothermal method. The morphology, crystal structure, surface groups, and luminescence properties of the as-produced La1-xEuxF3@PAA NPs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL) spectroscopy. The produced nanoparticles were (7±3) nm in size, water soluble, and buffer stable, with good photostability and biocompatibility. In vitro imaging revealed the low cytotoxicity of the as-synthesized NPs incubated with HeLa cancer cells. Thus, the colloidal La1-xEuxF3@PAA NPs exhibit great potential for use as optical imaging probes in biological applications.

Key words: Lanthanide nanoparticle, Hydrothermal, Aqueous dispersion, Efficient luminescence, Bioimaging

MSC2000: 

  • O648