物理化学学报 >> 2001, Vol. 17 >> Issue (10): 879-886.doi: 10.3866/PKU.WHXB20011004

研究论文 上一篇    下一篇

5-氟尿嘧啶卟啉化合物的合成和光谱性质

徐四川;张慧娟;孙照勇;冯娟;艾希成;张启元;张兴康;刘彦钦;韩士田   

  1. 中国科学院化学研究所分子科学中心 分子动态和稳态结构国家重点实验室, 北京 100080;河北师范大学化学系, 石家庄 050091
  • 收稿日期:2001-04-16 修回日期:2001-05-17 发布日期:2001-10-15
  • 通讯作者: 徐四川 E-mail:xusc@chem.pku.edu.cn

Synthesis and Spectroscopy Characteristics of 5-fluorouracil Porphyrin Compounds

Xu Si-Chuan;Zhang Hui-Juan;Sun Zhao-Yong;Feng Juan;Ai Xi-Cheng;Zhang Qi-Yuan;Zhang Xing-Kang;Liu Yan-Qin;Han Shi-Tian   

  1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Molecular Science Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080;Department of Chemistry, Hebei Normal University, Shijiazhuang 050091
  • Received:2001-04-16 Revised:2001-05-17 Published:2001-10-15
  • Contact: Xu Si-Chuan E-mail:xusc@chem.pku.edu.cn

摘要: 首次合成并用元素分析、红外光谱、核磁和质谱等表征了6种新的5氟尿嘧啶卟啉化合物. 对其紫外吸收、荧光性质和荧光寿命进行了研究,并与未修饰卟啉化合物光谱性质进行了比较. 5氟尿嘧啶卟啉化合物荧光寿命为7 ns,受环境取代基和溶剂的影响较小.

关键词: 5-氟尿嘧啶, 卟啉, 荧光寿命, 单光子计数

Abstract: 5fluorouracil porphyrin compounds are a new type of potential antitumor drugs. Six new 5fluorouracil porphyrin compounds were synthesized first and characterized by means of elemental analysis, IR, 1HNMR and MS. The six 5fluorouracil porphyrin compounds were studied by absorption spectra, steadystate fluorescence spectroscopy and timeresolved single photon measurement, comparing with their primary porphyrin compounds. The 5fluorouracil porphyrin compounds with plentiful excited states and fluorescence lifetime of 7 ns are little influenced by substituents and solvents, which may be advantageously used to make singlet oxygen radical.

Key words: 5-fluorouracil, Porphyrin, Fluorescence lifetime, Single photon measurement