物理化学学报 >> 2002, Vol. 18 >> Issue (02): 175-179.doi: 10.3866/PKU.WHXB20020217

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青霉素G钾盐在CTAB胶束中的水解及其抑制

钱俊红;郭荣   

  1. 扬州大学理学院化学化工系,扬州 225002
  • 收稿日期:2001-07-24 修回日期:2001-10-10 发布日期:2002-02-15
  • 通讯作者: 郭荣 E-mail:guorong@yzu.edu.cn

Inhibition of the Hydrolysis of Pen-K in CTAB Micelle Systems

Qian Jun-Hong;Guo Rong   

  1. Department of Chemistry, Science College, Yangzhou University, Yangzhou 225002
  • Received:2001-07-24 Revised:2001-10-10 Published:2002-02-15
  • Contact: Guo Rong E-mail:guorong@yzu.edu.cn

摘要: 以紫外光谱法研究了青霉素G钾盐(Pen-K)在十六烷基三甲基溴化铵(CTAB)胶束体系中的水解反应, 并探讨了水解反应机理.结果表明, CTAB胶束对Pen-K的水解具有抑制作用; Pen-K在CTAB胶束体系水解时,体系pH值的变化与在水中相似, 表明H+浓度对这种抑制作用影响较小.红外光谱和微极性研究表明,部分Pen-K钾盐定位于CTAB胶束栅栏层中, 增加了其稳定性.

关键词: 青霉素G钾盐(Pen-K), CTAB, 胶束, 水解, 抑制作用

Abstract: The hydrolysis reactions of Pen-K in water and in CTAB micelles have been studied by UV spectra. The results show that CTAB micelles can inhibit the hydrolysis, but the tendency of pH value change of the hydrolysis of Pen-K in the CTAB micelles is the same as that in water, which indicates that H+ concentration has small effect on the inhibition. The investigations of IR and micro-polarity show that the stability of Pen-K is increased by the location of some Pen-K in the railings of the CTAB micelles.

Key words: Penicillin potossiun salt(Pen-K), CTAB, Micelles, Hydrolysis, Inhibition