物理化学学报 >> 2003, Vol. 19 >> Issue (07): 610-615.doi: 10.3866/PKU.WHXB20030709

研究论文 上一篇    下一篇

镧三元配合物的合成、热稳定性及生物活性

杨锐;何水样;顾爱萍;文振翼;林翔;文辉忠   

  1. 西北大学化学系, 陕西省物理无机重点实验室,西安　710069; 1广西农业大学，南宁　530005
  • 收稿日期:2002-11-19 修回日期:2003-01-27 发布日期:2003-07-15
  • 通讯作者: 何水样 E-mail:xdhsy@263.net

Synthesis, Thermostability and Bioactivity of Mixed Ligand Complexes of Lanthanum with Alanine and Imidazoles

Yang Rui;He Shui-Yang;Gu Ai-Ping;Wen Zhen-Yi;Lin Xiang; Wen Hui-Zhong   

  1. Department of Chemistry, Northwest University and Shaanxi Key laboratory of PhysicoInorganic Chemistry, Xi’an　710069; 1Guangxi Agriculture University, Nanning　530005
  • Received:2002-11-19 Revised:2003-01-27 Published:2003-07-15
  • Contact: He Shui-Yang E-mail:xdhsy@263.net

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摘要： 在甲醇介质中,用La(ClO4)3•nH2O与丙氨酸（CH3CHNH2COOH,简称Ala）及咪唑（C3H4N2,简称Im）或苯并咪唑(C7H6N2,简称BenIm)合成出两个新三元配合物La(Ala)3Im(ClO4)3•3H2O(简称La1)和La(Ala)3BenIm(ClO4)3•H2O(简称La2).对配合物进行了容量分析及元素分析，确定了其组成.通过IR、UV、XRD及TG-DTG、DSC进一步研究了配合物的配位行为及热稳定性.生物活性试验表明该类配合物对5种菌均具有不同程度的抑制作用.

关键词: 镧三元配合物, 丙氨酸, 咪唑, 苯并咪唑, 热稳定性, 生物活性

Abstract: Two new ternary complexes La(Ala)3Im(ClO4)3•3H2O (La1) and La(Ala)3BenIm(ClO4)3•H2O (La2) of lanthanum perchlorate and DL-α-alanine (Ala),imidazole (Im) or benzimidazole (BenIm) have been synthesized.In methanol, the composition of the complexes is determined by EDTA capacity analysis and elemental analysis. The characters and thermostability have been studied by IR, UV, X-ray, and TG-DTG, DSC analysis. Bioactivity experiments show that the complexes have bacteriostasis effect for five variety of microbe.

Key words: Lanthanum ternary complex, Alanine, Imidazole, Benzimidazole, 　Thermostability, Bioactivity