物理化学学报 >> 2011, Vol. 27 >> Issue (08): 1900-1906.doi: 10.3866/PKU.WHXB20110817

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水溶液中两亲药物盐酸异丙嗪-表面活性剂体系的胶束化行为

KABIR-UD-DIN, KHAN Abbul Bashar, NAQVI Andleeb Z.   

  1. Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India
  • 收稿日期:2011-03-22 修回日期:2011-05-31 发布日期:2011-07-19
  • 通讯作者: KABIR-UD-DIN E-mail:kabir7@rediffmail.com
  • 基金资助:

    The project was supported by Department of Science and Technology's Science and Engineering Research Council Scheme of India (SR/FTP/CS-49/2007) for NAQVI Andleeb Z. and fellowship of University Grant Commission of India for KHAN Abbul Bashar.

Micellization Behavior of an Amphiphilic Drug Promethazine Hydrochloride-Surfactant System in an Aqueous Medium

KABIR-UD-DIN, KHAN Abbul Bashar, NAQVI Andleeb Z.   

  1. Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India
  • Received:2011-03-22 Revised:2011-05-31 Published:2011-07-19
  • Contact: KABIR-UD-DIN E-mail:kabir7@rediffmail.com
  • Supported by:

    The project was supported by Department of Science and Technology's Science and Engineering Research Council Scheme of India (SR/FTP/CS-49/2007) for NAQVI Andleeb Z. and fellowship of University Grant Commission of India for KHAN Abbul Bashar.

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摘要：

The behavior of the mixed amphiphilic drug promethazine hydrochloride (PMT) and cationic as well as nonionic surfactants was studied by tensiometry. The cmc values of the PMT-surfactant systems decrease at a surfactant mole fraction of 0.1 and it then becomes constant. The critical micelle concentration (cmc) values are lower than the ideal cmc (cmc*) values for PMT/TX-100, PMT/TX-114, PMT/Tween 20, and PMT/Tween 60 systems. For the PMT/Tween 40, PMT/Tween 80, PMT/CPC, and PMT/CPB systems the cmc values are close to the cmc* values. This indicates that PMT forms mixed micelles with these surfactants by attractive interactions. The surface excess (Γmax) decreases in the presence of surfactants. The rigid structure of the drug makes adsorption easier and the contribution of the surfactant at the interface decreases. The interaction parameters βm (for the mixed micelles) and βσ (for the mixed monolayer) are negative indicating attraction among the mixed components.

关键词: Promethazine hydrochloride, Cationic surfactant, Nonionic surfactant, Interaction parameter

Abstract:

The behavior of the mixed amphiphilic drug promethazine hydrochloride (PMT) and cationic as well as nonionic surfactants was studied by tensiometry. The cmc values of the PMT-surfactant systems decrease at a surfactant mole fraction of 0.1 and it then becomes constant. The critical micelle concentration (cmc) values are lower than the ideal cmc (cmc*) values for PMT/TX-100, PMT/TX-114, PMT/Tween 20, and PMT/Tween 60 systems. For the PMT/Tween 40, PMT/Tween 80, PMT/CPC, and PMT/CPB systems the cmc values are close to the cmc* values. This indicates that PMT forms mixed micelles with these surfactants by attractive interactions. The surface excess (Γmax) decreases in the presence of surfactants. The rigid structure of the drug makes adsorption easier and the contribution of the surfactant at the interface decreases. The interaction parameters βm (for the mixed micelles) and βσ (for the mixed monolayer) are negative indicating attraction among the mixed components.

Key words: Promethazine hydrochloride, Cationic surfactant, Nonionic surfactant, Interaction parameter