物理化学学报 >> 2014, Vol. 30 >> Issue (2): 365-370.doi: 10.3866/PKU.WHXB201312091

催化和表面科学 上一篇    下一篇

壳聚糖-纤维素硫酸钠聚电解质复合物膜对药物表观渗透系数的测试

朱丽英1,2, 晏晓琴1, 张红漫1, 林东强2, 姚善泾2, 江凌3   

  1. 1 南京工业大学理学院, 南京211816;
    2 浙江大学化学工程与生物工程系, 杭州310027;
    3 南京工业大学食品与轻工学院, 南京211816
  • 收稿日期:2013-10-06 修回日期:2013-12-09 发布日期:2014-01-23
  • 通讯作者: 姚善泾, 江凌 E-mail:sjyao@che.zju.edu.cn;jinagling@njut.edu.cn
  • 基金资助:

    江苏省自然科学基金(BK20131406,BK20130917)和国家自然科学基金(21106064)资助项目

Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films

ZHU Li-Ying1,2, YAN Xiao-Qin1, ZHANG Hong-Man1, LIN Dong-Qiang2, YAO Shan-Jing2, JIANG Ling3   

  1. 1 College of Sciences, Nanjing University of Technology, Nanjing 211816, P. R. China;
    2 Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
    3 College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 211816, P. R. China
  • Received:2013-10-06 Revised:2013-12-09 Published:2014-01-23
  • Contact: YAO Shan-Jing, JIANG Ling E-mail:sjyao@che.zju.edu.cn;jinagling@njut.edu.cn
  • Supported by:

    The project was supported by the Natural Science Foundation of Jiangsu Province, China (BK20131406, BK20130917) and National Natural Science Foundation of China (21106064).

摘要:

药物渗透系数是考察复合物膜的药物释放性能的重要参数. 本文以溶解性不同的两种药物扑热息痛和5-氨基水杨酸(5-ASA)为模型药物研究了其在壳聚糖-纤维素硫酸钠聚电解质复合物膜中的渗透性能. 结果表明:壳聚糖-纤维素硫酸钠聚电解质复合物膜的渗透性能与其溶胀性能密切相关;复合物膜中壳聚糖和纤维素硫酸钠的配比、相对分子量和pH值对膜的渗透性能和溶胀性能影响显著,以扑热息痛作为模型药物研究了壳聚糖-纤维素硫酸钠聚电解质复合物膜在模拟胃肠液中对药物的渗透性能. 通过调整该复合物膜的配方,可以使该膜分别实现胃、小肠和结肠定位释药的目的.

关键词: 聚电解质复合物膜, 壳聚糖, 纤维素硫酸钠, 溶胀, 渗透性, 药物控制释放

Abstract:

The permeability coefficient is a fundamental parameter for devices exploiting the controlled drugrelease behavior of films composed of chitosan and sodium cellulose sulfate (NaCS). Here, the transport of two model drugs with different solubilities, i.e., paracetamol and 5-aminosalicylic acid (5-ASA), was studied. The results showed that the permeability of the chitosan/NaCS film was closely related to the swelling properties. In addition, both the permeability and swelling properties of the chitosan/NaCS film were significantly influenced by the mass ratio of chitosan to NaCS, the molecular weights (Mw) of chitosan and NaCS, and the pH value. The permeability of paracetamol across the film was also investigated in simulated gastrointestinal solutions in in vitro tests. The results showed that the films have gastro-, intestine-, and colon-targeting drugrelease properties when they are exposed to simulated gastrointestinal fluids in sequence.

Key words: Polyelectrolyte complex film, Chitosan, Sodium cellulose sulfate, Swelling, Permeability, Controlled drug release

MSC2000: 

  • O647