物理化学学报 >> 1998, Vol. 14 >> Issue (06): 548-551.doi: 10.3866/PKU.WHXB19980613

研究简报 上一篇    下一篇

磷脂DHPC和短杆菌肽D相互作用的DSC研究

王邦宁, 谈夫   

  1. 中国科学院化学研究所,北京 100080
  • 收稿日期:1997-09-01 修回日期:1997-10-13 发布日期:1998-06-15
  • 通讯作者: 王邦宁

DSC Study of the Interactions of Phospholipid DHPC and Gramicidin D

Wang Bang-Ning, Tan Fu   

  1. Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080
  • Received:1997-09-01 Revised:1997-10-13 Published:1998-06-15
  • Contact: Wang Bang-Ning

关键词: 双-正-十七烷酰磷脂酰胆碱, 短杆菌肽D, 相变, 差示扫描量热法

Abstract:

Changes of the behavior of the thermotropic phase transitions of the phospholipid DHPC by the action of miniprotein gramicidin D (G.D) have been studied by differential scanning calorimetry. The experimental results demonstrated that G.D could not remove the pretransition of DHPC, but the pretransition peak and the main transition peak of DHPC were incorporated into a broad peak. The pretransition temperature and the main transition temperature of DHPC decreased to different ex-tent. The sums of the pretransition and main transition enthalpies of DHPC showed a lineally decreasing relationship with increasing the mole fraction x_g of gramicidin D.

Key words: 1,2-di-n-heptadecanoyl phosphatidylcholine, Gramicidin D, Phase transition, Differential scanning calorimetry