物理化学学报 >> 1992, Vol. 8 >> Issue (06): 795-798.doi: 10.3866/PKU.WHXB19920615

研究简报 上一篇    下一篇

邻醌式同系物的DSC研究

黄为钧; 周砚珠; 谈夫; 黄秀兰; 杨保津   

  1. 中国科学院化学研究所,北京 100080;中国科学院上海药物研究所
  • 收稿日期:1991-05-07 修回日期:1991-11-22 发布日期:1992-12-15
  • 通讯作者: 黄为钧

Study on O-Quinonoid Form Homologues by DSC

Huang Wei-Jun; Zhou Yan-Zhu; Tan Fu; Huang Xiu-Lan; Yang Bao-Jin   

  1. Institute Chemistry, Academia Sinica, Beijing 100080; Shanghai Institute of Materia Medica, Academia Sinica, Shangai 200031
  • Received:1991-05-07 Revised:1991-11-22 Published:1992-12-15
  • Contact: Huang Wei-Jun

关键词: 邻醌式物质, 差示扫描量热法, 药物热力学

Abstract: This paper presents the study on thermodynamic characteristics of phase transitions for tanshinone Ⅱ-A, tanshinone Ⅱ-B and saprorthoquinone (hereafter abbreviated to 1,2 and 3 respectively) by Differential Scanning Calorimetry (DSC). The relationships of their molecular structures with thermodynamic parameters were discussed. The experimental results obtained are listed in Table 2.
The differences of nominated compounds for their melting points, melting enthalpies and melting entropies are as follows:
T_m~1>T_m~3, ΔH_m~1>ΔH_m~3, ΔS_m~1=ΔS_m~3;
T_m~1>T_m~2, ΔH_m~1>ΔH_m~2, ΔS_m~1=ΔS_m~2.

Key words: o-quinonoid form materials, Differential Scanning Calorimetry, Thermodynamics of drug