物理化学学报 >> 1990, Vol. 6 >> Issue (06): 686-692.doi: 10.3866/PKU.WHXB19900610

研究论文 上一篇    下一篇

蛋白质二级结构预测的综合分析

王鹏良; 江寿平; 来鲁华; 徐小杰; 罗宇   

  1. 中国科学院上海生物化学研究所; 北京大学物理化学研究所
  • 收稿日期:1989-10-24 修回日期:1990-05-05 发布日期:1990-12-15
  • 通讯作者: 徐小杰

COMPREHENSIVE ANALYSIS OF THE PREDICTION OF PROTEIN'S SECONDARY STRUCTURE

Wang Peng-Liang; Jiang Shou-Ping; Lai Lu-Hua; Xu Xiao-Jie; Luo Yu   

  1. Shanghai Institute of Biochemistry; Academia Sinica Institute of Physicochemistry; Peking University
  • Received:1989-10-24 Revised:1990-05-05 Published:1990-12-15
  • Contact: Xu Xiao-Jie

摘要: 本文提出了一个蛋白质二级结构预测结果的综合分析方法, 它综合了常用的几种二级结构预测法(Chou-Fasman方法、Garnier方法, Cohen方法、疏水性分析法), 取各方法之长, 对由每种方法得到的有差别的结果进行综合分析, 经过这样处理, 可使蛋白质二级结构预测精度提高7%左右。

Abstract: A comprehensive analysis method of prediction of protein's secondary structure is presented. It combines several commonly used secondary structure prediction me-thods (Chou-Fasman method, Cohen method, Garnier method, hydrophobicity method). With taking the advantages of every method, the different results obtained from different prodiction methods were analyzed comprehensively. Through this treatment, the accuracy of prediction is about 7% higher than that of every individual method.