物理化学学报 >> 2005, Vol. 21 >> Issue (01): 1-5.doi: 10.3866/PKU.WHXB20050101

研究论文    下一篇

右旋布洛芬的低温热容

徐芬;孙立贤;谭志诚;李瑞莲;田琦峰;张涛   

  1. 中国科学院大连化学物理研究所材料热化学室,大连　116023；湖南省药品检验所,长沙　410001
  • 收稿日期:2004-06-11 修回日期:2004-07-15 发布日期:2005-01-15
  • 通讯作者: 孙立贤 E-mail:lxsun@dicp.ac.cn

Low Temperature Heat Capacity of (S)-ibuprofen

XU Fen;SUN Li-Xian;TAN Zhi-Cheng;LI Rui-Lian;TIAN Qi-Feng;ZHANG Tao   

  1. Materials ＆ Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian　116023; Hunan Institute of Drug Detection, Changsha　410001
  • Received:2004-06-11 Revised:2004-07-15 Published:2005-01-15
  • Contact: SUN Li-Xian E-mail:lxsun@dicp.ac.cn

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摘要： 在80～370 K温度范围内, 用精密自动绝热量热计准确测量了右旋布洛芬的摩尔热容.其固态右旋布洛芬测量值对折和温度X[X=f(T)]的拟和方程为:Cp,m(S)=－39.483X4－66.649X3＋95.196X2＋210.84X＋172.98;相应的液态的拟和方程为 :Cp,m(L)=7.191X3＋4.2774X2＋56.365X＋498.5.并计算得到右旋布洛芬相对于室温(298.15 K)的摩尔焓和摩尔熵.右旋布洛芬的熔点为(324.15±0.02) K.基于摩尔热容的测量,还可获得右旋布洛芬的纯度为99.44％.并对右旋布洛芬和消旋布洛芬的热容进行了对比研究.

关键词: 右旋布洛芬, 绝热量热, 热容

Abstract: Molar heat capacities of (S)-ibuprofen were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 370 K. Experimental heat capacities were fitted into a polynomial equation of heat capacities (Cp,m) with reduced temperature (X), [X=f(T)]. The polynomial equations for (S)-ibuprofen wereCp,m(S)= －39.483X4－66.649X3＋95.196X2＋210.84X＋172.98 in solid state and Cp,m(L)= 7.191X3＋4.2774X2＋56.365X＋498.5 in liquid state. The thermodynamic functions relative to the reference temperature of 298.15 K, HT－H298.15 and ST－S298.15, were derived for the(S)-ibuprofen. A fusion transition at Tm=(324.15±0.02) K was found from the Cp－T curve. The molar enthalpy and entropy of the fusion transition were determined to be (18.05±0.31) kJ•mol－1 and (55.71±0.95) J•mol－1•K－1, respectively. The purity of the (S)-ibuprofen was determined to be 99.44％ on the basis of the heat capacity measurement. Finally, the heat capacities of (S)-ibuprofen and racemic ibuprofen were compared.

Key words: (S)-ibuprofen, Adiabatic calorimetry, Heat capacity