物理化学学报 >> 2005, Vol. 21 >> Issue (02): 205-208.doi: 10.3866/PKU.WHXB20050219

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金属离子-脱氧胆酸-胆红素扩散体系中的周期沉淀

谢大弢;杨丽敏;吴瑾光;徐光宪   

  1. 北京大学重离子物理教育部重点实验室, 北京　100871; 北京大学化学与分子工程学院，北京　100871
  • 收稿日期:2004-07-15 修回日期:2004-09-10 发布日期:2005-02-15
  • 通讯作者: 谢大弢 E-mail:xdt@pku.edu.cn

Periodic Precipitation in Metal Ion-Deoxycholate-Bilirubinate Diffusion System

XIE Da-Tao;YANG Li-Min;WU Jin-Guang;XU Guang-Xian   

  1. MOE Key Laboratory of Heavy Ions Physics, Peking University, Beijing　100871; College of Chemistry and Molecular Engineering, Peking University, Beijing　100871
  • Received:2004-07-15 Revised:2004-09-10 Published:2005-02-15
  • Contact: XIE Da-Tao E-mail:xdt@pku.edu.cn

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摘要： 在金属离子-脱氧胆酸-胆红素扩散体系进行了周期沉淀的生长实验，得到了胆红素钙产生的周期沉淀图形.研究了胆红素、脱氧胆酸、Cu2＋和Ca2＋的相互作用以及它们对周期沉淀图形生长规律的影响，发现脱氧胆酸和胆红素会以复合胶团的形式在凝胶中进行扩散和反应，Ca2＋的作用会使胆红素从胶团中分离出来并产生胆红素钙沉淀；Cu2＋的作用则会使脱氧胆酸从胶团中分离出来产生脱氧胆酸铜沉淀；复合胶团的反应和扩散速度较慢，其生成周期沉淀的速度也很慢(约6个月，该结果与胆结石的情况较符合)；铜离子的作用会使复合胶团加速分解，从而也加快了图形的生长速度.

关键词: 胆结石, 周期沉淀, 胆红素, 反应扩散体系

Abstract: The periodic precipitation patterns of calcium bilirubinate were produced in the metal ion-deoxycholate-bilirubinate diffusion system. By considering of the interactions among the bilirubinate, deoxycholate, Cu2＋ and Ca2＋, the growth regulations of periodic precipitation patterns were investigated. It was found that the deoxycholate and bilirubinate could form the reunited micelle that could diffuse and react with metal ions in agar gels. When meeting with Ca2＋, the bilirubinate will separate out from micelle to produce calcium bilirubinate. When meeting with Cu2＋＋Ca2＋ ions, deoxycholate would first unite with Cu2＋ ions, then the bilirubinate would further separate out from micelle and react with Ca2＋ ions to produce calcium bilirubinate. Because the reunited micelle has bigger volume and slower speed in diffusion and reaction, its duration to produce precipitation pattern is much longer (roughly 6 months), which is more like the duration of gallstone growth. It was also found that when the copper ions present, the durations of the pattern formation became shorter.

Key words: Gallstone, Periodic precipitation, Bilirubinate, Reaction-diffusion system