物理化学学报 >> 2010, Vol. 26 >> Issue (07): 1847-1851.doi: 10.3866/PKU.WHXB20100612

胶体及界面化学 上一篇    下一篇

联萘酚与固体支撑双层类脂膜相互作用

安身景, 甘礼华, 陈柳华, 刘明贤, 朱大章, 徐子颉, 郝志显, 陈龙武   

  1. 同济大学化学系, 上海 200092
  • 收稿日期:2009-12-01 修回日期:2010-03-08 发布日期:2010-07-02
  • 通讯作者: 甘礼华 E-mail:ganlh@tongji.edu.cn

Interaction between [1,1'-Binaphthalene]-2,2'-diols and a Solid Supported Bilayer Lipid Membrane

AN Shen-Jing, GAN Li-Hua, CHEN Liu-Hua, LIU Ming-Xian, ZHU Da-Zhang, XU Zi-Jie, HAO Zhi-Xian, CHEN Long-Wu   

  1. Department of Chemistry, Tongji University, Shanghai 200092, P. R. China
  • Received:2009-12-01 Revised:2010-03-08 Published:2010-07-02
  • Contact: GAN Li-Hua E-mail:ganlh@tongji.edu.cn

摘要:

采用循环伏安法、交流阻抗法研究了联萘酚(BINOL)与固体支撑双层类脂膜(s-BLM)之间的相互作用. 结果表明, 联萘酚通过氢键、疏水作用与s-BLM发生相互作用. 随着相互作用时间的延长, 联萘酚/s-BLM体系中的氧化峰电流先增大后减小, 表明联萘酚逐渐破坏s-BLM的整体性, 诱导膜内部形成微孔通道. 联萘酚的浓度越大, 联萘酚分子通过s-BLM的渗透时间越短. 此外, 随着卵磷脂浓度和胆固醇含量的增加, s-BLM的膜电阻变大, 联萘酚渗透通过s-BLM速率减小, 导致其对s-BLM的渗透性能减弱.

关键词: 相互作用, 固体支撑双层类脂膜, 联萘酚, 渗透性

Abstract:

The interaction between [1,1'-binaphthalene]-2,2'-diols (BINOL) and a solid supported bilayer lipid membrane (s-BLM) was studied by cyclic voltammetry and alternating current (AC) impedance measurements. Results indicate that BINOL interacts with s-BLMthrough hydrogen bonding and hydrophobic interaction. The oxidation peak current of the BINOL/s-BLMsystem increases initially and then decreases with an increase in time. This suggests that BINOL gradually destroys the integrity of s-BLM and induces the formation of microchannels within the membrane. The infiltration time of BINOL through the s-BLM decreases as the BINOL concentration increases. With an increase in lecithin and cholesterol content, the membrane resistance of s-BLM increases and the infiltration rate of BINOL through the membrane decreases, which results in a reduction of the infiltration capacity of BINOL towards s-BLM.

Key words: Interaction, Solid supported bilayer lipid membrane, [1,1'-binaphthalene]-2,2'-diols, Infiltration

MSC2000: 

  • O646