物理化学学报 >> 2020, Vol. 36 >> Issue (9): 1912006.doi: 10.3866/PKU.WHXB201912006

所属专题: 精准纳米合成

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金纳米复合材料:制备、性质及其癌症诊疗应用

凌云云1,2, 夏云生1,*()   

  1. 1 安徽师范大学化学与材料科学学院,教育部功能分子固体重点实验室,安徽 芜湖 241000
    2 皖南医学院药学院,医用基础化学教研室,安徽 芜湖 241000
  • 收稿日期:2019-12-02 录用日期:2020-01-06 发布日期:2020-02-14
  • 通讯作者: 夏云生 E-mail:xiayuns@mail.ahnu.edu.cn
  • 作者简介:夏云生,国家基金委优秀青年科学基金获得者,安徽师范大学化学与材料科学学院教授,博士生导师。主要研究方向为纳米自组装及其生物分析应用
  • 基金资助:
    国家自然科学基金(21775004);皖南医学院中青年科研项目(WK201512)

Gold Based Nanocomposites: Fabrication Strategies, Properties, and Tumor Theranostic Applications

Yunyun Ling1,2, Yunsheng Xia1,*()   

  1. 1 Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, Anhui Province, P. R. China
    2 Department of Chemistry, School of Pharmacy, Wannan Medical College, Wuhu 241000, Anhui Province, P. R. China
  • Received:2019-12-02 Accepted:2020-01-06 Published:2020-02-14
  • Contact: Yunsheng Xia E-mail:xiayuns@mail.ahnu.edu.cn
  • Supported by:
    The project was supported by the National Natural Science Foundation of China(21775004);the Young Program of Wannan Medical College, China(WK201512)

摘要:

由于可调的局域表面等离子体共振、丰富的表面可修饰性、良好的生物相容性,金纳米粒子(AuNPs)在生物医药领域具有广泛的应用前景。金与其他无机纳米粒子相结合,既集成了单个组分的性质又有望开发组分间的协同效应,这为构建多功能金纳米复合材料提供了基础。本文阐述了金纳米复合材料的制备方法,包括一步合成法,种子生长法及非原位组装法等;对近期金纳米复合材料在癌症诊疗方面的应用进行总结;最后,讨论了多功能金纳米诊疗平台存在的主要问题及未来发展前景。

关键词: 金纳米复合材料, 制备, 集合性质, 协同效应, 癌症诊疗

Abstract:

Gold nanoparticles (AuNPs) have been widely applied in the biomedical field due to their tunable localized surface plasmon resonance (LSPR) properties, versatile surface modifiability, and favorable biocompatibility. With the in-depth study, individual AuNPs cannot meet the requirements for multifunctional biological applications. By combining AuNPs with other inorganic materials, material scientists and chemists have successfully prepared various gold-based nanocomposites (AuNCs), such as Au-metals, Au-semiconductors, Au-magnetic nanocomposites, etc. Furthermore, despite their compositions being the same, products with different topological morphologies (i.e. core@shell, yolk@shell, core-satellite, and Janus) can be fabricated by sophisticated chemistry. Based on their special collective properties and synergetic effects, multifunctional AuNCs have been proposed for tumor theranostic applications; their parts exhibit impressive imaging/therapeutic performances and present tremendous application perspectives for basic research and at a pre-clinical stage. For example, when Au is combined with porous drug carriers, its photothermal properties can promote drug release, which can be useful for developing intelligent drug delivery platforms. In addition, Au and magnetic material hybrids can be used in multimodal imaging and combination therapy, depending on the integration of its optical and magnetic properties. Moreover, when Au is combined with semiconductor material, either LSPR coupling effects or nonradiative energy transfer occurs between them, causing enhanced photothermal or photodynamic therapy. Therefore, in this review, we have highlighted the fabrication approaches of AuNCs including the one-step method, seed-mediated growth method, ex situ assembly method, etc. For the one-step method, we emphasize that Au and other components nucleate and grow concurrently, which is frequently employed for the preparation of Au based alloys. The key to synthesizing AuNCs by seed-mediated growth method is the degree of lattice matching between the different components and the interactions of their heterogeneous interfaces; if the crystal lattices are well-matched, AuNCs can be obtained by direct epitaxial growth. Furthermore, approaches including the introduction of a ligand/surfactant, intermediate layer, and molecular weak interactions into the heterogeneous interfaces can regulate the two components' interaction and fabricate various AuNCs. For the ex situ assembly method, prefabricated AuNPs and other nanoparticles can be assembled into AuCNs by electrostatic attraction, host-guest reaction, bio-recognition, covalent binding, etc. We also summarize the recent achievements of typical AuNCs (i.e. Au-MOF, Au-Fe3O4, and Au-Cu2xS) in tumor theranostic applications based on their collective properties and/or synergetic effects, respectively. Finally, the main problems and the future developments of this research field are also discussed.

Key words: Gold based nanocomposite, Fabrication strategy, Collective property, Synergetic effect, Tumor theranostic

MSC2000: 

  • O648