Acta Phys. -Chim. Sin. ›› 1995, Vol. 11 ›› Issue (09): 773-776.doi: 10.3866/PKU.WHXB19950902
• Communication •
Sun Hong-Mei, Xie Qian, Xie Gui-Ying, Zhou Jia-Ju, Xu Zhi-Hong, Li Zheng-Ming, Jia Guo-Feng, Wang Ling-Xiu
The biophore model of sulfonylurea herbicides (the training set contains 31 compounds) was obtained by using the advanced APEX-3D method. On the basis of the identilied biophore model, the activities of some known ALS inhibitors were predicted. Most of the predictions were in good agreement with experiments. The quality of the biophore model has been proved to be reliable. This research suggests a new approach for designing the new series of ALS inhibitors.
APEX(Activity Prediction Expert System)-3D
Sun Hong-Mei, Xie Qian, Xie Gui-Ying, Zhou Jia-Ju, Xu Zhi-Hong, Li Zheng-Ming, Jia Guo-Feng, Wang Ling-Xiu. The 3D Biophore Model of Sulfonylurea Herbicides Using APEX-3D Method[J].Acta Phys. -Chim. Sin., 1995, 11(09): 773-776.
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