Acta Phys. -Chim. Sin. ›› 2000, Vol. 16 ›› Issue (04): 356-361.doi: 10.3866/PKU.WHXB20000412

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Theoretic Studies on the Mechanism of Cations in Metallothioneins Polymerization

Hou Ting-Jun, An Yu, Liao Ning, Ru Bing-Gen, Xu Xiao-Jie   

  1. College of Chemistry and Molecular Engineering,College of Life Science,Peking University,Beijing 100871
  • Received:1999-06-23 Revised:1999-08-30 Published:2000-04-15
  • Contact: Xu Xiao-Jie


It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated. From the analyses of electrostatic potential, two binding sites of cations can be determined: The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole. The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.

Key words: Metallothioneines, Electrostatic potential, Negative electrostatic hole