Acta Phys. -Chim. Sin. ›› 2000, Vol. 16 ›› Issue (06): 568-572.doi: 10.3866/PKU.WHXB20000618

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Microcalorimetric Study of the Action of Selenium-containing Complexes on Growth Metabolism of Escherichia coli

Li Xi, Liu Yi, Wu Jun, Zhao Ru-Ming, Qu Song-Sheng   

  1. College of Chemistry and Environment Science,College of Life Science,Wuhan University,Wuhan 430072|School of Material Science and Technology,Wuhan University of Technology,Wuhan 430070|Department of Chemistry,Hubei Three Gorge University,Hubei 443000
  • Received:1999-10-14 Revised:2000-01-17 Published:2000-06-15
  • Contact: Liu Yi

Abstract:

The thermokinetic characteristics of the actions of selenium containing complexes on the growth metabolism of Escherichia coli were studied by means of microcalorimetry. It was found that at low concentration of Na2SeO3 and N, N′-methylene bisselenomorpholine promoting action on the growth of Escherichia coli, and at high concentration inhibiting action were observed but selenomorpholine had only inhibiting action. Considering both the half inhibition concentration(Ic50) and the rate constant (k), the inhibiting activity of selenium containing complexes studied is in the series of N, N′-methylene bisselenomorpholine > Na2SeO3 and selenomorpholine.

Key words: Microcalorimetry, Selenium-containing complexes, Escherichia coll, Growth metabolism