Acta Phys. -Chim. Sin. ›› 2001, Vol. 17 ›› Issue (02): 185-188.doi: 10.3866/PKU.WHXB20010220

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The Interaction of Methylene Blue and Bovine Serum Albumin in SDS Micelle System

Guo Rong;Fan Guo-Kang;Liu Tian-Qing;Jiao Xin-An   

  1. Department of Chemistry and Chemical Engineering, Science School,Yangzhou University;Yang Zhou　225002；Biological Science and Technology School, Yangzhou University, Yangzhou　225009
  • Received:2000-06-10 Revised:2000-09-20 Published:2001-02-15
  • Contact: Guo Rong

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Abstract: The interaction of methylene blue(MB) and bovine serum albumin(BSA) is investigated in the SDS micelle system which is simulated as one kind of coexisted albumin. The interaction parameters of MB and BSA and simulated albumin such as partition coefficient 辍ormal binding free energy 腉、average binding number n are calculated. The results show that most of MB is in the form of monomer in SDS micelle systems；the main interaction of MB and BSA is of static electric and Hbind force,and that of MB and simulated albumin is only of static electric force.

Key words: Methylene blue, Bovine serum albumin, Simulated albumin, SDS micelle