Abstract: Densities of serine in glucose-water and sucrose-water mixed solvents have been measured at 298.15 K by an oscillating-tube densimeter. Apparent molar volumes, limiting partial molar volumes and number of hydration of serine have been calculated. The transfer volumes from water to sugar-water mixtures have been obtained and discussed in terms of the structural hydration interaction model. The results obtained have been compared with that in glycerol-water and ethylene glycol-water mixtures. It is concluded that the magnitude of enhancement effect on volume is related to the number of OH groups.

Key words: Serine, Glucose-water mixed solvents, Sucrose-water mixed solvents, 　Limiting partial molar volumes, Structural interaction