Acta Phys. -Chim. Sin. ›› 2003, Vol. 19 ›› Issue (02): 105-108.doi: 10.3866/PKU.WHXB20030203

• ARTICLE • Previous Articles     Next Articles

Aspirin Synthesis On-line Measurement by Raman Spectroscopy

Li Wei-Hua;Lü Guo-Wei;Huang Lan;Gao Hong;Du Wei-Min   

  1. School of Physics, College of Chemistry and Molecular Engineering, Continue Education School, Peking University, Beijing 100871
  • Received:2002-04-05 Revised:2002-06-25 Published:2003-02-15
  • Contact: Du Wei-Min E-mail:wd00@pku.edu.cn

Abstract: In this paper, the process of aspirin synthesis was studied by using on-line Raman spectroscopy. Wavelet analysis has been applied to remove the fluorescent background from the Raman spectra, and the variation of components concentration was determined with Multi-wavelength Linear Regression Method. The on-line Raman spectroscopy provided direct information about the variation of components concentration on the reaction time in the synthesis process.

Key words: Raman spectroscopy, Multi-wavelength Linear Regression(MLR) method,  Wavelet analysis, Aspirin, On-line measurement