Acta Phys. -Chim. Sin. ›› 2004, Vol. 20 ›› Issue (02): 178-181.doi: 10.3866/PKU.WHXB20040214

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Preparation of VE Microcapsules and Its Controlled Release Characteristics

Bao De-Cai;Zhang Qiong-Gang;Liu Xiu-Dong;Ma Xiao-Jun;Yuan Quan   

  1. Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023; School of Science of Chemistry and Food, Bohai University, Jinzhou 121000
  • Received:2003-08-04 Revised:2003-10-27 Published:2004-02-15
  • Contact: Ma Xiao-Jun

Abstract: Monodisperse polystyrene(PS) microcapsules containing vitamin E(VE)were prepared by membrane emulsification-dying in liquid technique. The diameter of microcapsules was about 4 times the size of the pore diameter of Shirasu porous glass (SPG) membrane, and the coefficient of variation (CV) of the microcapsule size was less than 0.2, showing a good monodispersity. Furthermore, the effects of the ratio of PS to VE (m/m) and the diameter of microcapsules on the release characteristics were investigated. When the ratio of PS to VE (m/m) is 40/1, the permeability coefficients were 0.71×10-9 and 0.74×10-9 m•s-1 corresponding to the microcapsule diameters of 21.32 and 11.45 μm, and the concentrations of VE released were 8 and 12 mg•L-1 respectively, which conform to the optimal concentration in applications.

Key words: Membrane emulsification, Drying in liquid, Vitamin E, Microcapsule,  Controlled release