Abstract: Molecularly imprinted polymer (MIP) against dropropizine was synthesized using dropropizine as template, α-methyl acrylic acid as functional monomer, and trimethylolpropane trimethacrylate as crosslinking agent. Its application for separation and enrichment in solid phase extraction was investigated. It was found that, the imprinted polymer exhibited satisfactory performance in recognition and enrichment towards template, but it was not the case with non-imprinted polymer. The retention and separation of imprinted molecule with its structural analogues were also studied. The selectively separation was proved to be successful. The mechanism of imprinted recognition was also discussed here. With the help of PM3 semi-empirical method, the possible MIP system was simulated and compared with experimental results.

Key words: Dropropizine molecularly imprinted polymer, Solid phase extraction separation, Structural analogue, PM3 computer simulation method