Acta Phys. -Chim. Sin. ›› 2008, Vol. 24 ›› Issue (01): 176-178.doi: 10.3866/PKU.WHXB20080132

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Crystal Structure and Acid-Base Properties of Ozagrel

YANG Wei-Chun; JU Chuan-Chuan; FAN Su-Hua; SUN Hao-Ling; WANG Ke-Zhi   

  1. College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China; College of Chemistry and Chemical Engineering, Pingdingshan University, Pingdingshan 467002, Henan Province, P. R. China
  • Received:2007-09-04 Revised:2007-10-18 Published:2008-01-05
  • Contact: WANG Ke-Zhi E-mail:kzwang@bnu.edu.cn

Abstract: Crystal structure of ozagrel was determined by X-ray diffraction. The compound was crystallized in the orthorhombic space group P212121. The lattice parameters are, a=0.62522(6) nm, b=0.91897(8) nm, c=1.95789(18) nm, V=1.12492 (18) nm3, Z=4. The ground-and excited-state acid-base properties of ozagrel were studied using UV and emission spectrophotometric pH titrations, and the ground-and excited-state acidity constants were derived. The results showed that ozagrel acted as a pH induced on/off luminescence switch.

Key words: Ozagrel, Crystal structure, Acid-base property, Ultraviolet spectrum, Fluorescence spectrum

MSC2000: 

  • O641