Acta Phys. -Chim. Sin. ›› 2008, Vol. 24 ›› Issue (02): 281-288.doi: 10.3866/PKU.WHXB20080217

• ARTICLE • Previous Articles     Next Articles

Construction of PharmacophoreModel of EGFRTK Inhibitor

CHEN Xi; LIU Xin-Xia; HUANG Hui; HU Hui-Hui; JIANG Feng-Chao   

  1. School of Pharmacy, Tongji Medical Colloge, Huazhong Science and Technology University, Wuhan 430030, P. R. China
  • Received:2007-07-23 Revised:2007-11-02 Published:2008-01-26
  • Contact: JIANG Feng-Chao

Abstract: Epidermal growth factor receptor (EGFR) protein tyrosine kinases (TK) are attractive targets for anti-tumor drug design. So, a good pharmacophore model of EGFR TK inhibitors will be propitious to design new EGFR TK inhibitors. 80 compounds reported EGFR TK inhibitors which work at the ATP-binding domain were chosen to construct several pharmacophore models with the help of Catalyst software. Based on the action mechanism and the 3D structure of the EGFR tyrosine kinases, a fitting pharmacophore model (RMS=0.438, Correl=0.908, Weight=1.52, Config=17.36) including two aromatic ring centers (RA), an aliphatic hydrophobic core (HP) and a positive ionizable center (PI) was confirmed. This model revealed that the RA and HP group may act on ATP binding pocket, and the PI may act on the surface of ATP binding pocket. Therefore, this study could provide new hints for denovo design of new EGFR inhibitors with observable structure and predictable activity (screened in silico).

Key words: Antitumor drug, Computer aided drug design, EGFR inhibitor, Pharmacophore model


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