Abstract:

The molecule-ion interaction between a sugar and a salt is important and significant in biophysics and biochemistry. In this paper, powder X-ray diffraction (PXRD) technology was used to examine the molecule-ion adducts of a series of inorganic salts with β-cyclodextrin (β-CD). Our results indicate that there are considerable differences in the spectral properties of the PXRDs for adducts formed by similar inorganic salts and β-CD. Since their PXRD patterns are mainly dominated by β-CD, the large difference in spectral behavior reflects the diversity and complexity of molecule-ion interactions. The spectral differences were carefully compared by considering several factors such as the formation conditions of crystal adducts, the nature of the anions or cations and ionic charges. The diversity and complexity in adduct behaviors between sugars and salts in the crystal state should be very useful for scientific research and for the practical application of carbohydrates in biophysical chemistry, molecular biology, clinical medicine, nanoscience, and technology.

Key words: β-Cyclodextrin, Adduct, Molecule-ion interaction, Inorganic salt, Powder X-ray diffraction