Acta Phys. -Chim. Sin. ›› 2010, Vol. 26 ›› Issue (08): 2195-2199.doi: 10.3866/PKU.WHXB20100826

• COLLOID AND INTERFACE CHEMISTRY • Previous Articles     Next Articles

Coexistence of Oligonucleotide/Single-Chained Cationic Surfactant Vesicles with Precipitates

GUO Xia, LI Hua, GUO Rong   

  1. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu Province, P. R. China
  • Received:2010-03-01 Revised:2010-05-05 Published:2010-07-23
  • Contact: GUO Xia E-mail:guoxia@yzu.edu.cn
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (20603031).

Abstract:

It is well known that DNA (including oligonucleotide) and cationic surfactant can form insoluble complex. In this study, by turbidity measurement and TEM image, we found that the single-chained cationic surfactant could transform the oligonucleotide/single-chained cationic surfactant precipitates into vesicles and the vesicles coexist with the insoluble complex. The hydrophobic interaction between the cationic surfactant and the precipitates plays a key role in vesicle formation. Moreover, when the temperature reaches a specific value where the oligonucleotide begins to melt, the oligonucleotide/single-chained cationic surfactant vesicles form far easier. Thus, the more extended the oligonucleotide, the much easier for vesicle formation. As far as we know, the study about the oligonucleotide/cationic surfactant vesicle formation is very limited. Therefore, considering the growing importance and significance of DNA (including oligonucleotide)/amphiphile systems in medicine, biology, pharmaceutics, and chemistry, this study should provide some helpful information in further understanding these systems.

Key words: Surfactant, Self-assembly, Vesicle, Oligonucleotide, Transmission electron microscope

MSC2000: 

  • O648