微乳液成核-离子交联制备阿司匹林/壳聚糖纳米微球及其体外释放行为

doi:10.3866/PKU.WHXB20100842

Abstract

Abstract:

Chitosan (CS) nanosphere loaded aspirin (aspirin/CS) was prepared by nucleation and ionic crosslinking in an emulsion used for medical and pharmaceutical applications. Chemical component, morphology, size distribution, and crystal structure of nanospheres were characterized by Fourier transforminfrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic laser light scattering (DLLS), and X-ray powder diffraction (XRD). Results showed that the diameter of a typical aspirin/CS nanosphere is about 88 nm and the distribution is uniform. The crystal structure of CS does not change during the nucleation process. The crystallinity of aspirin is dramatically reduced and aspirin is almost amorphous in the nanosphere. The drug content (mass fraction), the drug loading efficiency, and the in vitro release profiles under different conditions were investigated using UV-Vis spectrophotometry. Results showed that the drug content was about 55%, the drug loading efficiency reached 42%, and the chitosan nanosphere displayed an excellent drug-controlled release behavior under the experimental conditions.

Key words: Chitosan, Nanosphere, Nucleation in emulsion, Drug-controlled release, Conformation

MSC2000:

O645

JIN Shu-Ping, FENG Lei, HE Wen-Yan, HAN Yu-Qi, WEI Yu-Juan. Preparation and Release Behavior in vitro of Aspirin/Chitosan Nanospheres by Nucleation and Ionic Crosslinking in Emulsion[J].Acta Phys. -Chim. Sin., 2010, 26(09): 2581-2588.

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Preparation and Release Behavior in vitro of Aspirin/Chitosan Nanospheres by Nucleation and Ionic Crosslinking in Emulsion

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