pH响应型P(HEMA/MAA)纳米微凝胶分散液的凝胶化行为和流变性能

doi:10.3866/PKU.WHXB20110815

Acta Phys. -Chim. Sin. ›› 2011, Vol. 27 ›› Issue (08): 1919-1925.doi: 10.3866/PKU.WHXB20110815

• SOFT MATTER • Previous Articles Next Articles

Rheological Properties and Gelation of pH-Responsive P(HEMA/MAA) Nano-Microgel Dispersions

SHEN Ying-Hua¹, LIU Hui-Min¹, LI Guo-Qing¹, ZHAI Zhi-Guo¹, SHU Xue-Feng², TAI Xiu-Mei³

1. College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China;
2. Institute of Applied Mechanics & Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China;
3. China Research Institute of Daily Chemical Industry, Taiyuan 030024, P. R. China

Received:2011-03-07 Revised:2011-06-02 Published:2011-07-19
Contact: SHEN Ying-Hua E-mail:shenyinghua@tyut.edu.cn
Supported by:
The project was supported by the Natural Science Foundation of Shanxi Province, China (2010011032-2) and Outstanding Innovative Program for Graduates of Shanxi Province, China (20103036).

Abstract

Abstract:

Poly((2-hydroxyethyl methacrylate)-co-(methacrylic acid)) (P(HEMA/MAA)) microgels with potential application in the restoration of damaged tissue were prepared. The phase transition behavior of P(HEMA/MAA) microgel dispersions at different pH values and concentrations as well as rheological properties of diluent and concentrated dispersions were investigated by tube inversion measurements and rheometry, respectively. The mechanism of the pH-induced physical gel phase transition was discussed. The results indicate that P(HEMA/MAA) microgel dispersions at a given concentration can be transformed into a macroscopic gel for gelation at a physiological pH. The mechanical strength of the P(HEMA-co-MAA) macroscopic gel (n_HEMA/n_MAA=8/2, pH=7.0) is the best and the elastic modulus (G') value can reach 7.58×10³ Pa. The swelling effects of the P(HEMA/MAA) microgel are different under different conditions, which results in a variety of apparent viscosities for the diluent dispersions. We deduce that the swelling behavior of the microgel particles can be divided into three stages from the outer parts of the particles to the inner parts. The gelation transitions of the concentrated dispersions are caused synergistically by space electrostatic interactions and hydrogen bonds of the neighboring microgel particles or between microgel particles and water molecules.

Key words: Gelation, P(HEMA/MAA) microgel, pH-responsive, Concentration of dispersion, Elastic modulus

MSC2000:

O648

SHEN Ying-Hua, LIU Hui-Min, LI Guo-Qing, ZHAI Zhi-Guo, SHU Xue-Feng, TAI Xiu-Mei. Rheological Properties and Gelation of pH-Responsive P(HEMA/MAA) Nano-Microgel Dispersions[J].Acta Phys. -Chim. Sin., 2011, 27(08): 1919-1925.

References

(1) Bradley, M.; Ramos, J.; Vincent, B. Langmuir 2005, 21, 1209.
(2) Martina, K.; Jan, S. P.;Walter, R. J. Am. Chem. Soc. 2009, 131, 3093.
(3) Shen, Y. H.; Zhang, X. Y.; Lu, J. J.; Zhang, A. Q.; Chen, K.; Li, X. Q. Colloids and Surfaces A: Physicochem. Eng. Aspects 2009, 350, 87.
(4) Amalvy, J. I.;Wanless, E. J.; Li, Y. Langmuir 2004, 20, 8992.
(5) Neyret, S.; Vincent, B. Polymer 1997, 38, 6129.
(6) Kaneda, I.; Vincent, B. J. Colloid Interface Sci. 2004, 274, 49.
(7) Oh, J. K.; Drumright, R.; Siegwart, D. J.; Siegwart, K. M. Prog. Polym. Sci. 2008, 33, 448.
(8) Sirpal, S.; Gattas-Asfura, K. M.; Leblanc, R. M. Colloids Surf. B 2007, 58, 116.
(9) Nolan, C. M.; Reyes, C. D.; Debord, J. D.; Garcia, A. J.; Lyon, L. A. Biomacromolecules 2005, 6, 2032.
(10) Jia, X. Q.; Yeo, Y.; Clifton, R. J.; Jia, X.; Yeo, Y.; Clifton, R. J.; Jiao, T.; Kohane, D. S.; Kobler, J. B.; Zeitels, S. M.; Langer, R. Biomacromolecules 2006, 7, 3336.
(11) Shivkumar, V. G.; Ester, C.; Mark, T. F. T.; Antonio, D.; Yuri, G.; Joachim,W.; Gaio, P. J. Phys. Chem. B 2010, 114, 10285.
(12) Shaun, C. H.; Craig, V. S. J.; Paul, A.; Fitz, G.; Erica, J.W. Langmuir 2010, 26, 14615.
(13) Saunders, B. R.; Saunders, J. M.; Tong, T. Soft Matter. 2007, 3, 486.
(14) Kapoor, Y.; Thomas, J. C.; Tan, G.; John, V. T.; Chauhan, A. Biomaterials 2009, 30, 867.
(15) Kim, B.; Peppas, N. A. J. Biomater. Sci. Polym. Edit. 2002, 13, 1271.
(16) Sarah, L.; Paul, M.; Christine, L. L.; Tony, J. F.; Brian, R. S. J. Colloid Interface Sci. 2007, 316, 367.
(17) Seifert, L. M.; Green, R. T. J. Biomed. Mater. Res. 1985, 9, 1043.
(18) Okano, T.; Aoyagi, T.; Kataoka, K.; Abe, K.; Sakurai, Y.; Shimadada, M.; Shinohara, I. J. Biomed. Mater. Res. 1986, 20, 919.
(19) Shen, Y. H.; Zhang, X. Y.; Li, X. Q.;Wu, L.W.; Zhao, Y. S.; Guo, J. Acta Polym. Sin. 2009, No. 9, 917. [申迎华, 张向英, 李晓琴, 武六旺, 赵彦生, 郭健. 高分子学报, 2009, No. 9, 917.]
(20) Limain, F.; Tanaka, T.; Kokufuta, E. Nature 1991, 349, 400.
(21) Tan, B. H. K.; Tam, K. C. Adv. Colloid Interface Sci. 2008, 136, 25.
(22) Tan, B. H. K.; Tam, K. C.; Lam, Y. C.; Tan, C. B. J. Rheol. 2004, 48, 915.
(23) Tan, B. H. K.; Tam, K. C.; Lam, Y. C.; Tan, C. B. Polymer 2004, 45, 5515.
(24) An, Y.; Xu, J.; Zhang, J.; Hu, C. G.; Li, G. Z.;Wang, Z. N.; Wang, Z. N.; Zhang, X. Y.; Zheng, L. Q. Sci. China B Chem. 2006, 36 (3), 234. [安娅, 徐军, 张晋, 胡长刚, 李干佐, 王志宁, 王仲妮, 张笑一, 郑利强. 中国科学B化学, 2006, 36 (3), 234.]
(25) Zhang, J. H. Acta Phys. -Chim. Sin. 2003, 19 (1), 90. [张建合. 物理化学学报, 2003, 19 (1), 90.]
(26) Andrew, M.; Howe, S.; Desrousseaux, L. S.; Lunel, J. T. Adv. Colloid Interface Sci. 2009, 147, 124.

[1]	ZHAO Cheng-Xiao, WANG Hai-Tao, LI Min. Research Progress in the Correlation between Gelation Properties and Solvent Parameters [J]. Acta Phys. -Chim. Sin., 2014, 30(12): 2197-2209.
[2]	XUE Min, MIAO Qing, FANG Yu. Synthesis and Gelation Properties of Cholesterol-Based New Low-Molecular-Mass Gelators [J]. Acta Phys. -Chim. Sin., 2013, 29(09): 2005-2012.
[3]	XU Wei-Wei, DU Ai, TANG Jun, CHEN Ke, ZOU Li-Ping, ZHANG Zhi-Hua, SHEN Jun, ZHOU Bin. Rapid Preparation of Highly Doped CuO/SiO₂ Composite Aerogels [J]. Acta Phys. -Chim. Sin., 2012, 28(12): 2958-2964.
[4]	LU Ting, WANG Xiao-Dong, ZHANG Tao. Gelation of n-Butanol by a Catanionic Surfactant System [J]. Acta Phys. -Chim. Sin., 2011, 27(02): 486-490.
[5]	ZHANG Hai-Quan, ZHAO Li-Cheng, ZHAI Jing,, LIU Wen-Ke, LI Ying, ZHANG Shuai. Influence of Interchain and Self Intrachain Aggregations on Photoluminescence of a Poly-Phenylenevinylene Derivative [J]. Acta Phys. -Chim. Sin., 2009, 25(06): 1156-1160.
[6]	LI Lin-Lin; CHEN Dong; DING Ming-Hui; TANG Fang-Qiong; MENG Xian-Wei; REN Jun; ZHANG Lin. Preparation and Controlled Drug Release Properties of Magnetic Microcapsules [J]. Acta Phys. -Chim. Sin., 2007, 23(12): 1969-1973.
[7]	Zhang Xiao-Hong, Fan Yu, Wu Shi-Kang. Effect of Sodium Dodecyl Sulfate on the Behavior of PEO-PPO-PEO Triblock Copolymer in Aqueous Solution [J]. Acta Phys. -Chim. Sin., 1999, 15(05): 390-397.
[8]	Niu Ai-Zhen, Zuo Ju, Ran Shao-Feng, Liang De-Hai, He Bing-Lin. Fractal Behavior of Span Process of Gelation by SAXS [J]. Acta Phys. -Chim. Sin., 1998, 14(11): 1030-1032.
[9]	Wang Yuan-Yang,Wu Dong,Fan Yan-Zhen,Sun Yu-Han,Chen Song-Ying. Mechanistic Study on the Effects of Preparation Parameters on the Structure Property of ZrO₂ Aerogels [J]. Acta Phys. -Chim. Sin., 1997, 13(07): 580-585.
[10]	Zuo Ju, Chen Tian-Hong, Wu Pei-Qiang, Zheng rong. A Study of Model Theory on Kinetics Mechanism of Crosslinking Copolymerization of Styrene with Divinylbenzene [J]. Acta Phys. -Chim. Sin., 1995, 11(01): 83-86.

Rheological Properties and Gelation of pH-Responsive P(HEMA/MAA) Nano-Microgel Dispersions

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Metrics

Comments

Recommended 0