吩噻嗪-Corrole 镓(III)配合物的合成、荧光及其光断裂DNA性质

doi:10.3866/PKU.WHXB201111291

Acta Phys. -Chim. Sin. ›› 2012, Vol. 28 ›› Issue (02): 465-469.doi: 10.3866/PKU.WHXB201111291

• PHOTOCHEMISTRY AND RADIATION CHEMISTRY • Previous Articles Next Articles

Synthesis, Fluorescence and DNA Photocleavage Activity of Phenothiazine-Corrole Gallium(III) Complexes

SHI Lei^1,2, JIANG Huan-Feng², YIN Wei¹, WANG Hua-Hua², WANG Hui³, ZHANG Lei², JI Liang-Nian³, LIU Hai-Yang²

1. Department of Chemistry, Guangdong University of Education, Guangzhou 510303, P. R. China;
2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China;
3. State Key Laboratory of Optoelectronics Materials and Technologies, Sun Yat-Sen University, Guangzhou 510275, P. R. China

Received:2011-10-13 Revised:2011-11-21 Published:2012-01-11
Contact: SHI Lei, LIU Hai-Yang E-mail:shil@gdei.edu.cn; chhyliu@scut.edu.cn
Supported by:
The project was supported by the National Natural Science Foundation of China (20971046, 21171057, 61178037, 11004256), Natural Science Foundation of Guangdong Province, China (10351064101000000), Open Fund of the State Key Laboratory of Optoelectronic Materials and Technologies (Sun Yat-Sen University), China, and Appropriative Researching Fund for Professors and Doctors, Guangdong University of Education, China (10ARF14).

Abstract

Abstract: Phenothiazine (PTZ)-corrole dyads 1-3 and their gallium(III) complexes 4-6 have been synthesized and characterized. The steady-state absorption and emission spectra and the time-resolved fluorescence decay profiles have been measured in toluene. The radiative and nonradiative rate constants have been obtained from the fluorescence quantum yields and monoexponential fluorescence lifetimes. The absorption spectra revealed that the gallium(III) corrole dyads exhibit stronger Soret bands and Q bands than free base corrole dyads. The fluorescence quantum yields of 1-3 are 0.156, 0.134, and 0.139, and the radiative rate constants are 4.02×10⁷, 3.47×10⁷, and 2.89×10⁷ s^-1, respectively. The fluorescence quantum yields of 4-6 are 0.502, 0.443, and 0.494, and the radiative rate constants are 20.9×10⁷, 16.78×10⁷, and 21.11×10⁷ s^-1, which are obviously higher than those of the corresponding free base corroles. The lifetimes of 4-6 are 2.40, 2.64, and 2.34 ns, respectively, which are somewhat shorter than those of the corresponding free base corroles. Agarose gel electrophoresis shows that these gallium(III) corrole dyads could cleave supercoiled DNA (form I) to give nicked-circular DNA (form II) under irradiation.

Key words: Corrole, Phenothiazine, Gallium(III), Fluorescence, DNA

MSC2000:

O644

SHI Lei, JIANG Huan-Feng, YIN Wei, WANG Hua-Hua, WANG Hui, ZHANG Lei, JI Liang-Nian, LIU Hai-Yang. Synthesis, Fluorescence and DNA Photocleavage Activity of Phenothiazine-Corrole Gallium(III) Complexes[J].Acta Phys. -Chim. Sin., 2012, 28(02): 465-469.

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Synthesis, Fluorescence and DNA Photocleavage Activity of Phenothiazine-Corrole Gallium(III) Complexes

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